First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves

Author(s):Show less -

Fernandes, Cassia Cristina ^[1] ; Chrystal, Pietro ^[2] ; Pereira, Alexandra Cristina ^[2] ; Colli, Ana Carla ^[3] ; Stenico, Livia ^[3] ; Ribeiro, Arthur Barcelos ^[4] ; Squarisi, Iara Silva ^[4] ; Candido, Ana Carolina ^[4] ; Tavares, Denise Crispim ^[4] ; Magalhaes, Lizandra Guida ^[4] ; Miller Crotti, Antonio Eduardo ^[3] ; Gomes Martins, Carlos Henrique ^[5] ; Dantas Miranda, Mayker Lazaro ^[6]

Affiliation

^[1] Inst Fed Educ Ciencia & Tecnol Goiano, Campus Rio Verde, BR-75901970 Rio Verde, Go - Brazil

^[2] Inst Fed Educ Ciencia & Tecnol Minas Gerais, Campus Pouso Alegre, BR-37550000 Pouso Alegre, MG - Brazil

^[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Univ Franca, Ctr Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil

^[5] Univ Fed Uberlandia, Inst Ciencias Biomed, Dept Microbiol, BR-38400902 Uberlandia, MG - Brazil

^[6] Inst Fed Educ Ciencia & Tecnol Triangulo Mineiro, Campus Uberlandia Ctr, BR-38411104 Uberlandia, MG - Brazil

• Document type: Journal article
• Source: Química Nova; v. 44, n. 5, p. 570-574, 2021.
• Web of Science Citations: 0

Abstract

Brazil has the greatest plant diversity in the world. Many species exhibit a wide range of phytochemical compounds which can be exploited in food, agronomic, pharmacological and medicinal plant industries. Therefore, the chemical composition and in vitro bioactivities of volatile oil from Psidium firmum fresh leaves (PfVO) were investigated for the first time. GC-FID and GC-MS analyses revealed 28 compounds in PfVO. The major ones were α-selinene (20.8%), β-caryophyllene (16.5%) and nerolidol (10.4%). Results showed that PfVO affected the growth of Leishmania amazonensis promastigote forms in a dose-dependent manner; its IC50 value was 14.05 µg/mL. PfVO also exhibited antibacterial activity against Salmonella enteritidis, Yersinia enterocolitica, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes; MIC values ranged from 25 μg/mL to 250 μg/mL. Moreover, PfVO promoted normal cell growth inhibition at 61.02 ± 1.97 µg/mL. Antiproliferative activity was observed against human tumor cell lines; IC50 values of MCF-7 cells, HeLa cells and M059J cells were 47.91 µg/mL, 73.78 µg/mL and 41.94 µg/mL, respectively. Results provided strong evidence of the promising potential of PfVO as a nature-based antileishmanial, antibacterial and antiproliferative agent. (AU)