Development of poly(epsilon-polycaprolactone)/hydroxyapatite composites for bone tissue regeneration

Author(s)

Backes, Eduardo Henrique ^[1] ; Beatrice, Cesar Augusto Goncalves ^[1] ; Shimomura, Kawany Munique Boriolo ^[2] ; Harb, Samarah Vargas ^[1] ; Pachane, Bianca Cruz ^[3] ; Selistre-de-Araujo, Heloisa Sobreiro ; Costa, Lidiane Cristina ^[1] ; Passador, Fabio Roberto ; Pessan, Luiz Antonio ^{[1, 4]}

Affiliation

^[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, Mat Engn Dept, Via Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Mat Engn Dept, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Lab Biochem & Mol Biol, Dept Physiol Sci, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[4] Univ Fed Sao Carlos, Inst Sci & Technol, Rua Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil

• Document type: Journal article
• Source: Journal of Materials Research; v. 36, n. 15, SI AUG 2021.
• Web of Science Citations: 0

Abstract

The incorporation of osteoconductive hydroxyapatite (HA) into poly(sigma-polycaprolactone) (PCL) may enhance the material hydrophilicity, protein adsorption, roughness, and consequently, bone formation. In this work, PCL/HA composites with 5, 10, and 25 wt% of HA were prepared by melt compounding followed by hot compression, and their properties such as torque, molecular weight, mechanical resistance, and viscosity were compared to neat PCL to understand the influence of the filler on the polymer stability and printability. The addition of 5 and 10 wt% of HA leads to properties similar to the neat PCL; therefore, these compositions were chosen to produce scaffolds by 3D printing. The scaffolds presented excellent printability and homogenous dispersion of the HA. The compressive strength modulus of both compressed samples and scaffolds is around 30 MPa, similar to cancellous bone. The presence of increasing HA content combined with surface treatment using NaOH enhanced osteoblast proliferation. (AU)

• FAPESP's process: 11/21313-1 - Study of the reaction kinetic and the addition of the metal deactivators in the grafting of maleic anhydride onto polypropylene in the presence and absence of the nanoparticles
• Grantee: Silvia Helena Prado Bettini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/09609-9 - Development of bioinspired scaffolds of PLA/bioactive ceramic fillers through 3D printing
• Grantee: Luiz Antonio Pessan
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/14151-4 - Development and characterization of bioactive PCL/TCP composites
• Grantee: Kawany Munique Boriolo Shimomura
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/11366-7 - Development of bio-inspired PLA/bioglass scaffolds via 3D printed
• Grantee: Eduardo Henrique Backes
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/26060-3 - Bioactive and bactericidal scaffolds for bone regeneration via 3D printing
• Grantee: Samarah Vargas Harb
• Support Opportunities: Scholarships in Brazil - Post-Doctoral