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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Benefits of Sebastiania hispida (Euphorbiaceae) extract and photobiomodulation therapy as potentially adjunctive strategies to be explored against snake envenoming

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Author(s):
Dourado, Doroty Mesquita [1, 2, 3] ; Matias, Rosemary [4] ; Kato da Silva, Baldomero Antonio [5] ; Milanesi, Fiorela Faria [6] ; Martello, Mayra Duarte [7] ; Marques dos Santos, Carlos Henrique [2] ; Lima Cardoso, Claudia Andrea [8] ; Vieira, Willians Fernando [1] ; Da Cruz-Hofling, Maria Alice [1]
Total Authors: 9
Affiliation:
[1] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
[2] Anhanguera Uniderp Univ, Lab Toxicol & Med Plants, Campo Grande, MS - Brazil
[3] Fed Univ Mato Grosso UFMS, Postgrad Program Infect & Parasit Dis, Campo Grande, MS - Brazil
[4] Anhanguera Uniderp Univ, Postgrad Program Environm & Reg Dev, Campo Grande, MS - Brazil
[5] Fed Univ Delta Parnaiba UFDPar, Postgrad Program Biomed Sci, Av Sao Sebastiao 2819, BR-64202020 Parnaiba, PI - Brazil
[6] Oswald Cruz Fdn MS, Hlth & Environm Biodivers Program, Campo Grande, MS - Brazil
[7] Fed Univ Mato Grosso UFMS, Postgrad Program Biochem & Mol Biol, Campo Grande, MS - Brazil
[8] Mato Grosso State Univ UEMS, Dept Chem, Dourados, MS - Brazil
Total Affiliations: 8
Document type: Journal article
Source: PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES; v. 20, n. 8 AUG 2021.
Web of Science Citations: 0
Abstract

The purpose of this study was to assess the topic use of Sebastiania hispida extract and low-level gallium-arsenide laser irradiation (GaAs, 904 nm) to reduce the local myonecrosis and edema of Bothrops moojeni snake venom-injected gastrocnemius. Wistar rats receiving intramuscular venom injection (VBm) were compared with saline control (S) and envenomed rats receiving local exposure to plant extract (VExt) or laser irradiation (VL). The phytochemistry and thin-layer chromatography of S. hispida extract indicated the presence of phenolic compounds like gallic acid and flavonoids including quercetin. Gastrocnemius of VExt and VL groups had a significant reduction of edema and creatine kinase (CK) activities and a greater Myogenin (MyoG) expression compared to VBm group, with the plant extract efficacy better than laser exposure. Reduction of edema and serum CK activities reflects a lessening of muscle damage, whereas the increase of MyoG indicates myoblast differentiation and acceleration of muscle repair. The S. hispida richness in phenolic compounds and flavonoids, such as the light modulatory ability to triggering a multitude of cell signalings likely underlie the positive outcomes. Our findings suggest both treatments as potential auxiliary tools to be explored in clinical trials in combination with anti-venom therapy after Bothropic snakebites. (AU)