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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neonatal anoxia increases nociceptive response in rats: Sex differences and lumbar spinal cord and insula alterations

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Author(s):
Helou, Ammir Yacoub [1] ; Martins, Daniel Oliveira [2] ; Arruda, Bruna Petrucelli [1] ; de Souza, Matheus Cerussi [1] ; Cruz-Ochoa, Natalia Andrea [1] ; Nogueira, Maria Ines [1] ; Chacur, Marucia [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Neurosci Lab, Ave Prof Lineu Prestes 2415, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Funct Neuroanat Pain, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE; v. 81, n. 8 AUG 2021.
Web of Science Citations: 0
Abstract

Neonatal anoxia is a well-known world health problem that results in neurodevelopmental deficits, such as sensory alterations that are observed in patients with cerebral palsy and autism disorder, for which oxygen deprivation is a risk factor. Nociceptive response, as part of the sensory system, has been reported as altered in these patients. To determine whether neonatal oxygen deprivation alters nociceptive sensitivity and promotes medium- and long-term inflammatory feedback in the central nervous system, Wistar rats of around 30 h old were submitted to anoxia (100% nitrogen flux for 25 min) and evaluated on PND23 (postpartum day) and PND90. The nociceptive response was assessed by mechanical, thermal, and tactile tests in the early postnatal and adulthood periods. The lumbar spinal cord (SC, L4-L6) motor neurons (MNs) and the posterior insular cortex neurons were counted and compared with their respective controls after anoxia. In addition, we evaluated the possible effect of anoxia on the expression of astrocytes in the SC at adulthood. The results showed increased nociceptive responses in both males and females submitted to anoxia, although these responses were different according to the nociceptive stimulus. A decrease in MNs in adult anoxiated females and an upregulation of GFAP expression in the SC were observed. In the insular cortex, a decrease in the number of cells of anoxiated males was observed in the neonatal period. Our findings suggest that oxygen-deprived nervous systems in rats may affect their response at the sensorimotor pathways and respective controlling centers with sex differences, which were related to the used stimulus. (AU)

FAPESP's process: 15/18415-8 - Gender differences in ontogenetic development, behavior and energy metabolism in rats subjected to neonatal anoxia: focus on the hippocampus, hypothalamus, leptin and glia cels
Grantee:Maria Inês Nogueira
Support Opportunities: Regular Research Grants
FAPESP's process: 14/22313-3 - Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring.
Grantee:Lívia Clemente Motta Teixeira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/05218-5 - Effect of photobiostimulation on different peripheral neuropathies in rats.
Grantee:Marucia Chacur
Support Opportunities: Regular Research Grants
FAPESP's process: 15/24256-0 - Study of the structures involved in orofacial pain and perspectives of combined treatment of low level laser and B vitamins in a model of trigeminal neuralgia
Grantee:Daniel de Oliveira Martins
Support Opportunities: Scholarships in Brazil - Post-Doctoral