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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study

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Author(s):
Alves, Mariana de Sa [1] ; de Oliveira Fugisaki, Luciana Ruano [1] ; dos Santos, Jessica Diane [1] ; Scorzoni, Liliana [1] ; Medina, Rebeca Previate [2] ; Siqueira Silva, Dulce Helena [2] ; Junqueira, Juliana Campos [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Medical Mycology; v. 59, n. 7, p. 744-747, JUL 2021.
Web of Science Citations: 0
Abstract

Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model. (AU)

FAPESP's process: 16/03395-4 - Antimicrobial activity of metabolites produced by Streptococcus mutans on Candida albicans in in vivo study models
Grantee:Jéssica Diane dos Santos
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/05226-5 - Evaluation of antimicrobial activity of metabolites produced by Streptococcus mutans on Candida albicans: in vitro study
Grantee:Mariana de Sá Alves
Support type: Scholarships in Brazil - Scientific Initiation