Cytotoxicity and effects of curcumin and cinnamaldehyde hybrids on biofilms of oral pathogens

Author(s)

Dos Santos, Vanessa Rodrigues ^[1] ; Caiaffa, Karina Sampaio ^[1] ; de Oliveira, Warlley Campos ^[1] ; Pereira, Jesse Augusto ^[1] ; Abuna, Gabriel Flores ; Polaquini, Carlos Roberto ^{[2, 3]} ; Regasini, Luis Octavio ^[2] ; Guiotti, Aimee Maria ^[4] ; Duque, Cristiane ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Aracatuba Sch Dent, Dept Prevent & Restorat Dent, Aracatuba, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Campinas UNICAMP, Fac Dent Piracicaba, Dept Restorat Dent, Piracicaba, SP - Brazil

^[4] Sao Paulo State Univ UNESP, Aracatuba Sch Dent, Dept Dent Mat & Prosthodont, Aracatuba, SP - Brazil

• Document type: Journal article
• Source: BIOFOULING; v. 37, n. 6, p. 591-605, JUL 3 2021.
• Web of Science Citations: 1

Abstract

The objective of the study was to evaluate the cytotoxicity and effect of curcumin-cinnamaldehyde hybrids (CCHs) on the biofilm of oral pathogens. Of the 18 hybrids tested, nine had an inhibitory effect on at least one of the bacterial species tested, with minimal inhibitory and bactericidal concentrations ranging from 9 to 625 mu g ml(-1). CCH 7 promoted a potent inhibitory effect against all the bacterial species tested and better compatibility than chlorhexidine (CHX). CCH 7 also presented a similar or improved effect over that of CHX, causing a reduction in bacterial metabolism and viability in single and dual-species biofilms. CCH 7 reduced by 86% and 34% the viability of multispecies biofilms formed by collection and clinical strains. It can be concluded that CCH 7 was cytocompatible at the minimal inhibitory concentration, presented anti-biofilm action against oral pathogens, and could act as an antimicrobial agent for application in endodontics. (AU)

• FAPESP's process: 17/05892-8 - Cytotoxic effect and antimicrobial action/antibiofilm of curcumin and cinnamaldehyde hybrids on microorganisms of endodontic interest
• Grantee: Vanessa Rodrigues dos Santos
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/15083-2 - Synthesis and biological evaluation of isobavachalcone (IBC) and analogs as potential agents against tuberculosis
• Grantee: Luis Octávio Regasini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors
• Grantee: Luis Octávio Regasini
• Support Opportunities: Regular Research Grants