Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes) as a Functional Food in Gestational Diabetes Mellitus Before and After Fetus Implantation

Author(s)

Caetano, Erika Leao Ajala ^[1] ; Viroel, Fabia Judice Marques ^[1] ; Laurino, Leticia Favara ^[1] ; Camargo, Isabella Ferreira ^[1] ; Castro, Raquel de Mendonca Rosa ^[1] ; Pickler, Thaisa Borim ^[1] ; Jozala, Angela Faustino ^[1] ; Grotto, Denise ^[1] ; Gerenutti, Marli ^[2]

Affiliation

^[1] Univ Sorocaba, Sorocaba, SP - Brazil

^[2] Pontifical Catholic Univ Sao Paulo, Sao Paulo - Brazil

• Document type: Journal article
• Source: International Journal of Medicinal Mushrooms; v. 23, n. 9, p. 15-27, 2021.
• Web of Science Citations: 0

Abstract

Through preclinical tests, this study evaluated the effects of Agaricus brasiliensis consumption in rats with streptozotocin (STZ)-induced gestational diabetes mellitus (GDM) and considered its potential as a functional food. The perinatal period was evaluated considering the daily exposure to A. brasiliensis before and after GDM induction (Ab(b), and Ab(a), respectively). Nutritional characterization of A. brasiliensis was performed (centesimal composition, beta-glucans, phenolic compounds, and antioxidant activity). Concerning maternal reproductive development, the parameters assessed were maternal weight, oral glucose tolerance, hemogram, biochemical markers, redox status in blood, biochemical markers in amniotic fluid, and reproductive performance. Moreover, emblyofetal development was evaluated. A. brasiliensis reduced hyperglycemia before STZ induction and maintained levels similar to the GDM group after STZ induction. A. brasiliensis also reduced alanine aminotransferase, aspartate aminotransferase, triglyceride, and cholesterol levels and increased high-density lipoprotein levels. The mushroom also presented antioxidant activity, improving parameters of oxidative stress. Furthermore, it protected the conceptus from actions promoted by STZ concerning external abnormalities. Thus, daily intake of A. brasiliensis in GDM suggests its potential as a functional food because the nutritional characterization of this mushroom indicated important antioxidant activity, improving lipid and glycemic functions and preventing oxidative damage from STZ. (AU)

• FAPESP's process: 15/24566-9 - Pre-clinical studies with Agaricus blazei, Lentinula edodes and Ganoderma lucidum, aiming to reduce the maternal and fetal damage caused by gestational diabetes.
• Grantee: Marli Gerenutti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/05765-5 - Assessment of biochemical and antioxidant parameters in rats exposed to Lentinula edodes (shiitake) and its possible use in metabolic disturbances
• Grantee: Denise Grotto
• Support Opportunities: Regular Research Grants