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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

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Author(s):
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Brandao, Bruna B. [1, 2, 3] ; Madsen, Soren [4] ; Rabiee, Atefeh [4] ; Oliverio, Matteo [5, 6, 7] ; Ruiz, Gabriel P. [8, 9] ; Ferrucci, Danilo L. [8] ; Branquinho, Jessica L. [1, 3] ; Razolli, Daniela [10, 11] ; Pinto, Silas [8, 9] ; Nielsen, Thomas S. [4] ; Festuccia, William T. [12] ; Martins, Adriano S. [1, 3, 13] ; Guerra, Beatriz A. [1, 3, 8] ; Knittel, Thiago L. [8, 9] ; Sogaard, Ditte [14] ; Larsen, Steen [14, 15] ; Helge, Jorn W. [14] ; Brandauer, Josef [16] ; Velloso, Licio A. [10] ; Emanuelli, Brice [4] ; Kornfeld, Jan-Wilhelm [17] ; Kahn, C. Ronald [2] ; Vienberg, Sara G. [4] ; Zierath, Juleen R. [4, 18] ; Treebak, Jonas T. [4] ; Mori, Marcelo A. [1, 3, 8, 9, 10, 19]
Total Authors: 26
Affiliation:
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[1] Univ Fed Sao Paulo, Dept Biophys, BR-04023062 Sao Paulo - Brazil
[2] Harvard Med Sch, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 - USA
[3] Univ Fed Sao Paulo, Program Mol Biol, BR-04044020 Sao Paulo - Brazil
[4] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth Sci, Integrat Metab & Environm Influences, DK-2200 Copenhagen - Denmark
[5] Max Planck Inst Metab Res, Lab Noncoding Principles Energy Homeostasis, D-50931 Cologne - Germany
[6] Cologne Cluster Excellence Cellular Stress Respon, Res Area 1, D-50931 Cologne - Germany
[7] Univ Hosp Cologne, Apoptosis Signaling & Therapy Resistance Grp, Internal Med 1, D-50937 Cologne - Germany
[8] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, BR-13083862 Sao Paulo - Brazil
[9] Univ Estadual Campinas, Inst Biol, Program Genet & Mol Biol, BR-13083862 Sao Paulo - Brazil
[10] Univ Estadual Campinas, Obes & Comorbid Res Ctr, BR-13083862 Campinas - Brazil
[11] Sao Francisco Univ, Lab Cell & Mol Biol, BR-12916900 Braganca Paulista, SP - Brazil
[12] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol, BR-05508000 Sao Paulo - Brazil
[13] Maimonides Hosp, Dept Orthoped, Brooklyn, NY 11219 - USA
[14] Univ Copenhagen, Ctr Hlth Aging, Dept Biomed Sci, DK-2200 Copenhagen - Denmark
[15] Med Univ Bialystok, Clin Res Ctr, PL-15089 Bialystok - Poland
[16] Gettysburg Coll, Dept Hlth Sci, Gettysburg, PA 17325 - USA
[17] Univ Southern Denmark, Dept Biochem & Mol Biol, DK-5230 Odense - Denmark
[18] Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm - Sweden
[19] Univ Estadual Campinas, Expt Med Res Cluster, BR-13083862 Campinas - Brazil
Total Affiliations: 19
Document type: Journal article
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; v. 117, n. 38, p. 23932-23941, SEP 22 2020.
Web of Science Citations: 5
Abstract

DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations. (AU)

FAPESP's process: 17/03423-0 - Characterization of the tissue-specific alterations in protein expression with aging and caloric restriction in C. elegans
Grantee:Thiago Leite Knittel
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/06238-6 - Dicer deletion in adipocytes and its influence in cardiovascular diseases
Grantee:Adriano Silva Martins
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/01316-7 - Dicer, miRNAs and the control of mitochondrial function in the context of aging and caloric restriction
Grantee:Marcelo Alves da Silva Mori
Support type: Regular Research Grants
FAPESP's process: 15/03292-8 - Study of the role of GCN1 in the genesis of metabolic diseases in mice
Grantee:Beatriz Alves Guerra
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/04079-8 - Identification of mechanisms responsible for the beneficial effects of caloric restriction
Grantee:Bruna Brasil Brandao
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/21635-8 - Study of the role of miR-203-3p in adipose tissue metabolism and in the pathogenesis of metabolic diseases in mice
Grantee:Gabriel Palermo Ruiz
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics
Grantee:Marcelo Alves da Silva Mori
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/04377-2 - Study of Dicer effects on mitochondrial function, metabolism and aging in C. elegans nematodes
Grantee:Silas Pinto da Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/07975-8 - Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training
Grantee:Marcelo Alves da Silva Mori
Support type: Regular Research Grants