A voltammetric sensor based on a carbon black and chitosan-stabilized gold nanoparticle nanocomposite for ketoconazole determination

Author(s)

Silva, Lais Pereira ^[1] ; Silva, Tiago Almeida ^[2] ; Moraes, Fernando Cruz ^[1] ; Fatibello-Filho, Orlando ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Vicosa, Dept Chem, BR-36570900 Vicosa, MG - Brazil

• Document type: Journal article
• Source: ANALYTICAL METHODS; v. 13, n. 38 AUG 2021.
• Web of Science Citations: 0

Abstract

A modified glassy carbon electrode with carbon black (CB) and gold nanoparticles (AuNPs) within a crosslinked chitosan (CTS) film is proposed in this work. The electroanalytical performance of the modified CB-CTS-AuNPs/GCE has been evaluated towards the voltammetric sensing of ketoconazole (KTO), a widespread antifungal drug. The nanocomposite was characterized by scanning electron microscopy, X-ray diffraction spectroscopy, and electrochemistry experiments. The evaluation of the electrochemical behaviour of KTO on the proposed modified electrode shows an irreversible oxidation process at a potential of +0.65 V (vs. Ag/AgCl (3.0 mol L-1 KCl)). This redox process was explored to carry out KTO sensing using square-wave voltammetry. The analytical curve was linear in the KTO concentration range from 0.10 to 2.9 mu mol L-1, with a limit of detection (LOD) of 4.4 nmol L-1 and a sensitivity of 3.6 mu A L mu mol(-1). This modified electrode was successfully applied to the determination of KTO in pharmaceutical formulations and biological fluid samples. (AU)

• FAPESP's process: 20/01050-5 - Development and application of electrochemical and photoelectrochemical sensors for the determination of emerging contaminants in environmental samples
• Grantee: Orlando Fatibello Filho
• Support Opportunities: Regular Research Grants