Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits

Author(s)

De Freitas, Silvio Henrique ^{[1, 2]} ; Muller, Alois Foltran ^{[2, 3]} ; Fadel, Thais Ribeiro ^{[2, 3]} ; Bessi, Wellington Henrique ^{[2, 3]} ; Sampaio Doria, Renata Gebara ^{[1, 2]} ; Ito Yamauchi, Kelly Cristiane ^{[2, 4]} ; Strefezzi, Ricardo De Francisco ^{[1, 2]} ; Vidane, Atanasio Serafim ^{[2, 5]} ; Fortulan, Carlos Alberto ^{[6, 2]} ; Ambrosio, Carlos Eduardo ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn FZEA, Vet Med Dept ZMV, Pirassununga, SP - Brazil

^[2] Univ Sao Paulo, Fac Anim Sci & Food Engn, Vet Med Dept ZMV, Pirassununga, SP - Brazil

^[3] Univ Sao Paulo, Fac Anim Sci & Food Engn FZEA, Postgrad Program Anim Biosci PPBA, Pirassununga, SP - Brazil

^[4] Fac Vet Med, Dept Vet Clin & Surg, Cuiaba, MT - Brazil

^[5] Eduardo Mondlane Univ, Dept Clin, Fac Vet Med, Maputo - Mozambique

^[6] Univ Sao Paulo, Dept Mech Engn, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Acta Cirurgica Brasileira; v. 36, n. 7 2021.
• Web of Science Citations: 0

Abstract

ABSTRACT Purpose To analyze and compare the reactions at the interface between the composite, composed of fragmented heterologous mineralized bone matrix (MOMHF) and polymethylmethacrylate (PMMA), and the rabbit’s tibias, through macroscopic evaluation and scanning electron microscopy (SEM) in different periods. Methods In this study, 12 New Zealand adult rabbits were used (E1: n = 3, E2: n = 3, E3: n = 3 and E4: n = 3). They had the right tibial defects filled with composite and were evaluated immediately after surgery and at 30, 60, 90, and 120 days. Results The composites were incorporated and integrated into the recipient beds in 100% of the cases, defined by the MOMHF osseointegration and the PMMA fibrointegration, with no sign of infection, migration, or rejection. Conclusions The behavior of the composites in the recipient beds demonstrates that these biomaterials have the potential to be used in bone defect repairs, offering, thus, better quality of life to the orthopedic patient. (AU)

• FAPESP's process: 15/25723-0 - ANALYSIS OF INTERFACES BETWEEN COMPOSITE CONSTING OF CANINE AND BOVINE HETEROLOGOUS MINERALIZED TRABECULAR BONE MATRIX (MOMHTc and MOMHTb) ASSOCIATED TO POLYMETHYLMETHACRYLATE (PMMA) AND/OR TO CHITOSAN AND THE BONE DEFECT OF RABBIT TIBIA
• Grantee: Silvio Henrique de Freitas
• Support Opportunities: Regular Research Grants