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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HPV-induced condylomata acuminata treated by Photodynamic Therapy in comparison with trichloroacetic acid: A randomized clinical trial

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Author(s):
Buzza, Hilde Harb [1, 2] ; Stringasci, Mirian Denise [1] ; de Arruda, Semira Silva [1, 3] ; Crestana, Rita Helena Schiavone [4] ; de Castro, Cynthia Aparecida [5] ; Bagnato, Vanderlei Salvador [6, 1] ; Inada, Natalia Mayumi [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, IFSC, Grp Opt, Trabalhador Sao Carlense St, 400 Jd Arnold Schimid, BR-13566590 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Biol & Hlth Sci Ctr, Sao Carlos, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Med, Sao Carlos, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Morphol & Pathol, Sao Carlos, SP - Brazil
[6] Texas A&M Univ, College Stn, TX - USA
Total Affiliations: 6
Document type: Journal article
Source: Photodiagnosis and Photodynamic Therapy; v. 35, SEP 2021.
Web of Science Citations: 0
Abstract

Objectives: This is a randomized controlled clinical trial comparing Photodynamic Therapy (PDT) and the application of trichloracetic acid (TAA) in the treatment of HPV condyloma in the perianal and vulva regions. Design, Randomised controlled, open label, trial. They were allocated to each treatment following randomization by a computer program. Setting: Women Health Ambulatory in Sao Carlos city, Sao Paulo State in the Brazil. Participants: 36 patients evaluated. 31 patients fulfilled the study requirements. Intervention: Photodynamic Therapy (PDT) versus trichloracetic acid (TAA). The PDT protocol used the prodrug methyl aminolevulinate incubated for 3 hours and irradiation at 630 nm (100 J/cm(2)). In the treatment using TAA, warts received a small amount of acid using a cotton swab. Both treatments were repeated weekly until the lesions disappeared completely or until 10 sessions were completed. Main Outcome Measure: Clinical analysis. Followup between 12 and 30 months after the complete treatment. Results: A total of 16 patients were treated with PDT and 15 patients with TAA. A complete response rate of 60% for TAA and 63% for PDT, with a recurrence rate of 33% for TAA and 0% for PDT. Conclusion: PDT appears not only to treat lesions due to physical destruction of condyloma and subclinical lesions, but also to modulate the immune system and/or also to decrease the local viral load, suggesting a lower recurrence compared to the TAA group. (AU)

FAPESP's process: 16/14033-6 - Basic studies of the combination of photothermal and photodynamic effects in application of a new modality for the Cancer treatment
Grantee:Hilde Harb Buzzá
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Projects - Thematic Grants