Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Shedding light on toxicity of SARS-CoV-2 peptides in aquatic biota: A study involving neotropical mosquito larvae (Diptera: Culicidae)

Full text
Author(s):
Show less -
Mendonca-Gomes, Juliana Moreira [1] ; Charlie-Silva, Ives [2] ; Guimaraes, Abraao Tiago Batista [3] ; Estrela, Fernanda Neves [3] ; Calmon, Marilia Freitas [4] ; Miceli, Rafael Nava [5] ; Sanches, Paulo R. S. [6] ; Bittar, Cintia [4] ; Rahal, Paula [4] ; Cilli, Eduardo M. [6] ; Ahmed, Mohamed Ahmed Ibrahim [7] ; Vogel, Christoph F. A. [8, 9] ; Malafaia, Guilherme [3, 10, 11]
Total Authors: 13
Affiliation:
Show less -
[1] Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Farmacol, Inst Ciencias Biomed, Sao Paulo, SP - Brazil
[3] Inst Fed Goiano, Programa Pos Grad Conservacao Recursos Nat Cerr, Urutai, Go - Brazil
[4] Univ Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP - Brazil
[5] SeMAE Serv Municipal Autonomo Agua & Esgoto, Sao Paulo, SP - Brazil
[6] Univ Estadual Paulista, Inst Quim, Araraquara, SP - Brazil
[7] Assiut Univ, Dept Plant Protect, Fac Agr, Assiut 71526 - Egypt
[8] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 - USA
[9] Univ Calif Davis, Ctr Hlth & Environm, Davis, CA 95616 - USA
[10] Univ Fed Goias, Programa Pos Grad Biotecnol & Biodiversida, Goiania, Go - Brazil
[11] Univ Fed Uberlancia, Programa Pos Grad Ecol & Conservacao Recursos Nat, Uberlandia, MG - Brazil
Total Affiliations: 11
Document type: Journal article
Source: Environmental Pollution; v. 289, NOV 15 2021.
Web of Science Citations: 0
Abstract

Knowledge about how the COVID-19 pandemic can affect aquatic wildlife is still extremely limited, and no effect of SARS-CoV-2 or its structural constituents on invertebrate models has been reported so far. Thus, we investi-gated the presence of the 2019-new coronavirus in different urban wastewater samples and, later, evaluated the behavioral and biochemical effects of the exposure of Culex quinquefasciatus larvae to two SARS-CoV-2 spike protein peptides (PSPD-2002 and PSPD-2003) synthesized in our laboratory. Initially, our results show the contamination of wastewater by the new coronavirus, via RT-qPCR on the viral N1 gene. On the other hand, our study shows that short-term exposure (48 h) to a low concentration (40 mu g/L) of the synthesized peptides induced changes in the locomotor and the olfactory-driven behavior of the C. quinquefascitus larvae, which were asso-ciated with increased production of ROS and AChE activity (cholinesterase effect). To our knowledge, this is the first study that reports the indirect effects of the COVID-19 pandemic on the larval phase of a freshwater invertebrate species. The results raise concerns at the ecological level where the observed biological effects may lead to drastic consequences. (AU)

FAPESP's process: 19/19939-1 - Effects of marine pharmaceuticals in ZFL cell line
Grantee:Ives Charlie da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 20/05761-3 - Study of the action of synthetic peptides as antivirals against SARS-CoV-2 (COVID-19) and combined evaluation with commercial anti-inflammatories
Grantee:Eduardo Maffud Cilli
Support Opportunities: Regular Research Grants