Nanocellulose/palygorskite biocomposite membranes for controlled release of metronidazole

Author(s)

Meneguin, Andreia ^[1] ; Pacheco, Guilherme ^[2] ; Silva, Jhonatan Miguel ^[2] ; de Araujo, Francisca Pereira ^[3] ; Silva-Filho, Edson Cavalcanti ^[3] ; Bertolino, Luiz Carlos ^[4] ; Barud, Hernane da Silva ^[2]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, Campus Ville, BR-14800903 Araraquara, SP - Brazil

^[2] Centro Univ Araraquara, Res Ctr Biotechnol, BR-14801340 Araraquara, SP - Brazil

^[3] Univ Fed Piaui, Interdisciplinary Lab Adv Mat, LIMAV, Campus Univ Ministro Petronio Portella, BR-64049550 Teresina, Piaui - Brazil

^[4] Ctr Mineral Technol, Rio De Janeiro - Brazil

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 188, p. 689-695, OCT 1 2021.
• Web of Science Citations: 0

Abstract

The incorporation of drugs in nanocomposites can be considered a potential strategy for controlled drug release. In this study, a nanocomposite based on bacterial cellulose and the palygorskite clay (BC/PLG) was produced and loaded with metronidazole (MTZ). The samples were characterized using X-ray diffraction (XRD) Spectroscopy, thermal analysis (TG/DTG) and Scanning Electron Microscopy (SEM). The barrier properties were determined to water vapor permeability (WVP). Adsorption tests with PLG were performed using MTZ and drug release profile of the membranes was investigated. The results indicated that PLG increased the crystallinity of the nano composites, and greater thermal stability when PLG concentration was 15.0% (BC/PLG15) was observed. WVP of the samples also varied, according to the clay content. Adsorption equilibrium was achieved from 400 mg/L of the PLG and a plateau in the MTZ release rates from BC/PLG was observed after 30 min. Therefore, the results of this study show the potential of these nanocomposite membranes as a platform for controlled drug release. (AU)

• FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
• Grantee: Edgar Dutra Zanotto
• Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 19/19817-3 - Bioresponsive systems based on retrograded starch/pectin containing cellulose nanofibers as a strategy for 5-ASA colonic delivery in the treatment of Inflammatory Bowel Disease
• Grantee: Andréia Bagliotti Meneguin
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 18/25512-8 - Biocelulose-based Cell Culture Platform
• Grantee: Hernane da Silva Barud
• Support type: Regular Research Grants