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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanocellulose/palygorskite biocomposite membranes for controlled release of metronidazole

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Author(s):
Meneguin, Andreia [1] ; Pacheco, Guilherme [2] ; Silva, Jhonatan Miguel [2] ; de Araujo, Francisca Pereira [3] ; Silva-Filho, Edson Cavalcanti [3] ; Bertolino, Luiz Carlos [4] ; Barud, Hernane da Silva [2]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, Campus Ville, BR-14800903 Araraquara, SP - Brazil
[2] Centro Univ Araraquara, Res Ctr Biotechnol, BR-14801340 Araraquara, SP - Brazil
[3] Univ Fed Piaui, Interdisciplinary Lab Adv Mat, LIMAV, Campus Univ Ministro Petronio Portella, BR-64049550 Teresina, Piaui - Brazil
[4] Ctr Mineral Technol, Rio De Janeiro - Brazil
Total Affiliations: 4
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 188, p. 689-695, OCT 1 2021.
Web of Science Citations: 0
Abstract

The incorporation of drugs in nanocomposites can be considered a potential strategy for controlled drug release. In this study, a nanocomposite based on bacterial cellulose and the palygorskite clay (BC/PLG) was produced and loaded with metronidazole (MTZ). The samples were characterized using X-ray diffraction (XRD) Spectroscopy, thermal analysis (TG/DTG) and Scanning Electron Microscopy (SEM). The barrier properties were determined to water vapor permeability (WVP). Adsorption tests with PLG were performed using MTZ and drug release profile of the membranes was investigated. The results indicated that PLG increased the crystallinity of the nano composites, and greater thermal stability when PLG concentration was 15.0% (BC/PLG15) was observed. WVP of the samples also varied, according to the clay content. Adsorption equilibrium was achieved from 400 mg/L of the PLG and a plateau in the MTZ release rates from BC/PLG was observed after 30 min. Therefore, the results of this study show the potential of these nanocomposite membranes as a platform for controlled drug release. (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 19/19817-3 - Bioresponsive systems based on retrograded starch/pectin containing cellulose nanofibers as a strategy for 5-ASA colonic delivery in the treatment of Inflammatory Bowel Disease
Grantee:Andréia Bagliotti Meneguin
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/25512-8 - Biocelulose-based Cell Culture Platform
Grantee:Hernane da Silva Barud
Support type: Regular Research Grants