Menstrual cycle impacts adipokine and lipoprotein responses to acute high-intensity intermittent exercise bout

Author(s)

Olean-Oliveira, Tiago ^[1] ; Figueiredo, Caique ^[1] ; de Poli, Rodrigo Araujo Bonetti ^[2] ; Lopes, Vithor Hugo Fialho ^[2] ; Jimenez-Maldonado, Alberto ^[3] ; Lira, Fabio Santos ^[1] ; Antunes, Barbara Moura ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Postgrad Program Movement Sci, Exercise & Immunometabolism Res Grp, Dept Phys Educ, Sao Paulo, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Phys Educ, Postgrad Program Movement Sci, Lab Physiol & Sport Performance LAFIDE, Sch Sci, Bauru, SP - Brazil

^[3] Univ Autonoma Baja Calif, Fac Deportes Campus Ensenada, Ensenada, Baja California - Mexico

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 122, n. 1 SEP 2021.
• Web of Science Citations: 0

Abstract

Due to hormonal fluctuation, the menstrual cycle impacts inflammatory response and lipid metabolism; moreover, the anti-atherogenic and anti-inflammatory effects of exercise in this cycle, mainly high-intensity intermittent exercise (HIIE), need to be examined. Therefore, the aim of the current study was to investigate the influence of menstrual cycle phases on adipokine and lipoprotein responses after acute HIIE sessions in healthy women. Fourteen women (age: 24 +/- 2 years; BMI: 22.79 +/- 1.89 kg center dot m(2)) were recruited to perform two HIIE sessions (10 x 1 min running at 90% of maximum aerobic velocity, with 1 min recovery); one during the follicular phase (FP) and other during the luteal phase (LP), randomly. Blood samples were collected at rest, immediately, and 60 min after HIIE sessions. Macrophage inflammatory protein-1 alpha (MIP-1 alpha), leptin, adiponectin, total cholesterol, triacylglycerol (TAG), HDL-c, and glucose concentrations were analyzed. At rest, higher MIP-1 alpha concentrations were observed during the LP compared to FP (p = 0.017). Likewise, leptin (p = 0.050), LDL-c (p = 0.015), and non-HDL (p = 0.016) were statistically higher in the LP. In contrast, the adiponectin/leptin ratio was lower in the LP compared to the ratio found in the FP (p = 0.032). Immediately post-HIIE sessions, in both menstrual phases, higher TAG (p = 0.001) and HDL-c (p = 0.001) concentrations were found, which returned to resting levels after 60 min. In conclusion, adipokine and lipoprotein responses after a single HIIE session are regulated by the phase of the menstrual cycle, contributing to inflammatory conditions, and demonstrating the importance of considering the phases of the menstrual cycle for the periodization of physical training. (AU)

• FAPESP's process: 19/26378-6 - M1 and M2 macrophage polarization in individuals with low and high cardiorespiratory fitness: potential role of adipose tissue, aging and leptin
• Grantee: Caíque de Figueiredo
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/22726-0 - Neural, neuromuscular and physiological responses caused by sodium bicarbonate supplementation in supramaximal performance: real effect or placebo effect?
• Grantee: Vithor Hugo Fialho Lopes
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/17445-1 - Influence of high intensity interval training on time to exhaustion during a supramaximal effort: biomolecular and neuromuscular responses
• Grantee: Rodrigo de Araujo Bonetti de Poli
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/11340-3 - Evaluation of the inflammatory response in peripheral blood mononuclear cells of sedentary individuals: role of physical exercise and capsaicin
• Grantee: Tiago Olean Oliveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/25282-5 - B-alanine supplementation associated with high-intensity interval training on modulations of the immune-endocrine response in healthy adults
• Grantee: Barbara de Moura Mello Antunes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral