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B-alanine supplementation associated with high-intensity interval training on modulations of the immune-endocrine response in healthy adults

Grant number: 19/25282-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2020
Effective date (End): September 30, 2022
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Alessandro Moura Zagatto
Grantee:Barbara de Moura Mello Antunes
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Chronic use of ergogenic resources, such as b-alanine, is widely investigated given its positive effects on performance and physical training quality. However, is unclear the knowledge about the effects of the quality of physical training, enhanced by b-alanine, on the anti-inflammatory responses, typically associated with exercise training, on systemic and tissue levels. Thus, the purpose of the present project will be to investigate the effects of 12 weeks of b-alanine supplementation associated with high-intensity interval training on intramuscular and systemic inflammatory modulations. In this perspective, 20 healthy volunteers will be recruited and divided randomly into b-alanine (6.4 or placebo (dextrose) groups that, after 6 weeks of supplementation, will performed 6 weeks of high-intensity interval training, associated with supplementation, in a sprint protocol (10 sprints with 1min effort: 1 min pause) with frequency of three sessions/weekly. Pre and post-intervention, body composition, nutritional habits, cardiorespiratory fitness, blood collection and muscle biopsy will be collected. (AU)

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