| Full text | |
| Author(s): |
Mengarda, Ana C.
[1]
;
Silva, Marcos P.
[1]
;
Cirino, Maria E.
[1]
;
Morais, Thiago R.
[1]
;
Conserva, Geanne A. A.
[2]
;
Lago, Joao Henrique G.
[2]
;
de Moraes, Josue
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Guarulhos, Nucleo Pesquisa Doencas Negligenciadas, Praca Tereza Cristina 88, BR-07023070 Guarulhos, SP - Brazil
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210180 Santo Andre, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Phytotherapy Research; v. 35, n. 9, p. 5154-5162, SEP 2021. |
| Web of Science Citations: | 2 |
| Abstract | |
Schistosomiasis is a widespread human parasitic disease currently affecting over 200 million people, particularly in poor communities. Chemotherapy for schistosomiasis relies exclusively on praziquantel (PZQ). Previous studies have shown that licarin A (LIC-A), a dihydrobenzofuran neolignan, exhibited in vitro antiparasitic activity against Schistosoma mansoni adult worms. This study aimed to investigate the potential of LIC-A, isolated as main metabolite from leaves of Nectandra oppositifolia Nees \& Mart. (Lauraceae), as an antischistosomal agent orally active in schistosomiasis animal model. PZQ was used as a reference compound. As result, LIC-A showed, at a single dose of 400 mg/kg, to be able to partially cure infected mice (worm burden reductions of similar to 50%). Parasite eggs, that are responsible for a variety of pathologies and transmission of schistosomiasis, were also moderately inhibited by LIC-A (egg burden reductions of similar to 50%-60%). Furthermore, it was observed that LIC-A achieved a slight reduction of hepatomegaly and splenomegaly. Collectively, although LIC-A was partially active when administered orally, these results give support for the antiparasitic potential LIC-A as lead compound for novel antischistosomal agent. (AU) | |
| FAPESP's process: | 16/22488-3 - Drug repositioning for neglected diseases: identification of novel anthelmintic agents |
| Grantee: | Josué de Moraes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects |
| Grantee: | João Henrique Ghilardi Lago |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |
| FAPESP's process: | 19/25289-0 - In vitro anthelmintic activity of praziquantel and mefenamic acid nanocarreated |
| Grantee: | Vinícius de Castro Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 19/25905-2 - Preclinical evaluation for oral administration of nanostructured formulations containing drugs with anthelmintic activity |
| Grantee: | Ana Carolina Araujo Mengarda |
| Support Opportunities: | Scholarships in Brazil - Doctorate |