| Full text | |
| Author(s): |
Maria Fernanda Hussid
[1]
;
Felipe Xerez Cepeda
[2]
;
Camila P. Jordão
[3]
;
Rafaela R. P. Lopes-Vicente
[4]
;
Leslie Virmondes
[5]
;
Keyla Y. Katayama
[6]
;
Ezequiel F. de Oliveira
[7]
;
Luis V. F. Oliveira
[8]
;
Fernanda Marciano Consolim-Colombo
;
Ivani Credidio Trombetta
Total Authors: 10
|
| Affiliation: | [1] Universidade Nove de Julho - Brasil
[2] Universidade Nove de Julho - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas - Brasil
[4] Universidade Nove de Julho - Brasil
[5] Universidade Nove de Julho - Brasil
[6] Universidade Nove de Julho - Brasil
[7] Universidade Nove de Julho - Brasil
[8] Centro Universitário de Anápolis - Brasil
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Cardiologia; v. 116, n. 4, p. 795-803, 2021-04-16. |
| Abstract | |
Abstract Background: Obesity affects adolescence and may lead to metabolic syndrome (MetS) and endothelial dysfunction, an early marker of cardiovascular risk. Albeit obesity is strongly associated with obstructive sleep apnea (OSA), it is not clear the role of OSA in endothelial function in adolescents with obesity. Objective: To investigate whether obesity during adolescence leads to MetS and/or OSA; and causes endothelial dysfunction. In addition, we studied the possible association of MetS risk factors and apnea hypopnea index (AHI) with endothelial dysfunction. Methods: We studied 20 sedentary obese adolescents (OA; 14.2±1.6 years, 100.9±20.3kg), and 10 normal-weight adolescents (NWA, 15.2±1.2 years, 54.4±5.3kg) paired for sex. We assessed MetS risk factors (International Diabetes Federation criteria), vascular function (Flow-Mediated Dilation, FMD), functional capacity (VO2peak) and the presence of OSA (AHI>1event/h, by polysomnography). We considered statistically significant a P<0.05. Results: OA presented higher waist (WC), body fat, triglycerides, systolic (SBP) and diastolic blood pressure (DBP), LDL-c and lower HDL-c and VO2peak than NWA. MetS was presented in the 35% of OA, whereas OSA was present in 86.6% of OA and 50% of EA. There was no difference between groups in the AHI. The OA had lower FMD than NWA (6.17±2.72 vs. 9.37±2.20%, p=0.005). There was an association between FMD and WC (R=-0.506, p=0.008) and FMD and SBP (R=-0.493, p=0.006). Conclusion: In adolescents, obesity was associates with MetS and caused endothelial dysfunction. Increased WC and SBP could be involved in this alteration. OSA was observed in most adolescents, regardless of obesity. (Arq Bras Cardiol. 2021; 116(4):795-803) (AU) | |
| FAPESP's process: | 15/11738-6 - Sleep study, lung function, respiratory muscle strength and validation of two instruments of clinical outcome in patients with myasthenia gravis: Myasthenia gravis Quantitative testing form and MG Composite Scale. |
| Grantee: | Ezequiel Fernandes de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/03274-0 - Diet and exercise improves metabolic, inflammatory changes and sympathovagal balance in patients with metabolic syndrome and obstructive sleep apnea |
| Grantee: | Felipe Xerez Cepêda Fonseca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 16/16831-7 - Metabolic/inflammatory markers and sympatho-vagal balance in patients with metabolic syndrome and obstructive sleep apnea: effect of hypocaloric diet and exercise training |
| Grantee: | Felipe Xerez Cepêda Fonseca |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |