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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Alkaloids from the Leaves of Annona crassiflora and Their Cytotoxic Activity

Full text
Author(s):
Pena-Hidalgo, Miguel [1] ; Furtado, Luciana Costa [2] ; Costa-Lotufo, Leticia V. [2] ; Ferreira, Marcelo J. P. [1] ; Santos, Deborah Y. A. C. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biociencias, Dept Bot, Rua Matao 277, Cidade Univ, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, Av Prof Lineu Prestes 1524, Cidade Univ, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 31, n. 2, p. 244-248, APR 2021.
Web of Science Citations: 0
Abstract

Aporphines are a class of alkaloids mostly reported in Magnoliids. The genus Annona, Annonaceae, presents great structural diversity of these compounds. Chemical investigation of leaves from Annona crassiflora Mart. resulted in the identification of an undescribed aporphine alkaloid, which was named as crassiflorine, in addition to six known analogues: anonaine, annoretine, xylopine, tetrahydropalmatrubine, litseglutine B, and stephalagine. The structure of crassiflorine was established through 1D and 2D NMR data in combination with HREIMS and IR analyses. The cytotoxic activity for all tested compounds was marginal (IC50 > 30 mu M) against breast carcinoma (MCF-7) and colorectal carcinoma (HCT-116) cell lines. (AU)

FAPESP's process: 17/18235-5 - Anticancer potential of isolated substances from Streptomyces SP. recovered from ascidian Euherdmania SP
Grantee:Luciana Costa Furtado
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds
Grantee:Leticia Veras Costa Lotufo
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 07/06511-6 - Population analysis of Annona crassiflora Mart. from Cerrado: AFLP and alkaloid profile
Grantee:Déborah Yara Alves Cursino dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07543-0 - Pesticide activities of acetogenins of native species of Annonaceae from Brazilian Savanna
Grantee:Déborah Yara Alves Cursino dos Santos
Support Opportunities: Regular Research Grants