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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

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Author(s):
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Wang, Weisheng [1] ; Schuette, Peter J. [1] ; La-Vu, Mimi Q. [1] ; Torossian, Anita [2] ; Tobias, Brooke C. [1] ; Ceko, Marta [3] ; Kragel, Philip A. [4] ; Reis, V, Fernando M. C. ; Ji, Shiyu [5] ; Sehgal, Megha [6] ; Maesta-Pereira, Sandra [2] ; Chakerian, Meghmik [5] ; Silva, Alcino J. [7, 5, 6] ; Canteras, Newton S. [8] ; Wager, Tor [4] ; Kao, Jonathan C. [9] ; Adhikari, Avishek [5]
Total Authors: 17
Affiliation:
[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA
[2] Univ Calif Los Angeles, Los Angeles, CA - USA
[3] Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 - USA
[4] Univ Colorado, Boulder, CO 80309 - USA
[5] Reis, Fernando M. C., V, Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA
[6] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA - USA
[7] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 - USA
[8] Univ Sao Paulo, Dept Anat, Sao Paulo - Brazil
[9] Univ Calif Los Angeles, Elect & Comp Engn, Los Angeles, CA - USA
Total Affiliations: 9
Document type: Journal article
Source: eLIFE; v. 10, SEP 1 2021.
Web of Science Citations: 0
Abstract

Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (PMd) are necessary for initiating escape from innate threats via a projection to the dorsolateral periaqueductal gray (dlPAG). We now show that in mice PMd-cck cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity can also predict future escape. Furthermore, PMd inhibition decreases escape speed from both innate and conditioned threats. Inhibition of the PMd-cck projection to the dlPAG also decreased escape speed. Intriguingly, PMd-cck and dlPAG activity in mice showed higher mutual information during exposure to innate and conditioned threats. In parallel, human functional magnetic resonance imaging data show that a posterior hypothalamic-to-dlPAG pathway increased activity during exposure to aversive images, indicating that a similar pathway may possibly have a related role in humans. Our data identify the PMd-dlPAG circuit as a central node, controlling escape vigor elicited by both innate and conditioned threats. (AU)

FAPESP's process: 17/08668-1 - In vivo study of GABAergic and glutamatergic neuronal populations of the periaqueductal gray matter in response to different kinds of threat
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 15/23092-3 - Signaling pathways involved in fear memory to predatory threats
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/05432-9 - Neural bases of fear and aggression
Grantee:Newton Sabino Canteras
Support Opportunities: Research Projects - Thematic Grants