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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of the Composition of Copaifera (Fabaceae) Leaf Extracts with Potential Antioxidant Activity by Metabolomics Approach

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Author(s):
Mangabeira da Silva, Jonas Joaquim [1] ; Casoti, Rosana [1] ; Figueiredo, Sonia Aparecida [1] ; Vieira Fonseca, Maria Jose [1] ; Rogez, Herve [2] ; Gomes Heleno, Vladimir Constantino [3] ; Bastos, Jairo Kenupp [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Fed Para, Ctr Valorizacao Compostos Bioativos Amazonia, BR-66075110 Belem, Para - Brazil
[3] Univ Franca, Nucleo Pesquisa Ciencia & Tecnol, BR-14404600 Franca, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 31, n. 5 OCT 2021.
Web of Science Citations: 0
Abstract

Copaifera species display several biological activities, such as antimicrobial, antinociceptive, gastroprotective, and anti-inflammatory. Some of these activities are directly associated with the presence of compounds with significant antioxidant properties. Determination of the chemical composition of the leaf extracts of nine Copaifera species was performed, by attributing which compounds are responsible for the antioxidant activity based on metabolomic analysis, through qualitative chemical analysis by liquid chromatography coupled with high-resolution mass spectrometry and in vitro antioxidant activity assay. Eighty-one compounds were found in all analyzed extracts, being 60 peaks totally identified as phenolic compounds (galloylquinic acids and flavonoids), organic acids, coumarins, and terpenes. Orthogonal partial least-squares discriminant analysis indicated that six galloylquinic acids and one flavonoid were the most active compounds. The chemical composition of the nine Copaifera species leaves revealed different classes of compounds. (AU)

FAPESP's process: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants