| Full text | |
| Author(s): Show less - |
de Sa Alves, Mariana
[1]
;
de Sa Rodrigues, Nayara
[1]
;
Bandeira, Celso Muller
[1]
;
Chagas, Jose Francisco Sales
[2]
;
Pascoal, Maria Beatriz Nogueira
[2]
;
Nepomuceno, Gabrielle Luana Jimenez Teodoro
[3]
;
da Silva Martinho, Herculano
[3]
;
Alves, Monica Ghislaine Oliveira
[4, 5]
;
Mendes, Maria Anita
[6]
;
Dias, Meriellen
[6]
;
Alves, Levy Anderson Cesar
[6]
;
Almeida, Janete Dias
[1]
Total Authors: 12
|
| Affiliation: | [1] Sao Paulo State Univ Unesp, Dept Biosci & Diag, Inst Sci & Technol, BR-12245000 Sao Jose Dos Campos - Brazil
[2] Hosp Pontifical Catholic Univ Campinas, Dept Head & Neck Surg, BR-13086900 Campinas - Brazil
[3] Univ Fed ABC, Ctr Ciencias Nat & Humanas CCNH, Av Estados 5001, BR-09210580 Santo Andre - Brazil
[4] Univ Mogi das Cruzes, Sch Dent, BR-08780911 Mogi Das Cruzes - Brazil
[5] Anhembi Morumbi Univ, Sch Med, BR-03164000 Sao Jose Dos Campos - Brazil
[6] Univ Sao Paulo, Polytech Sch, Dept Chem Engn, Dempster MS Lab, BR-05508040 Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | METABOLITES; v. 11, n. 10 OCT 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Oral squamous cell carcinoma (OSCC) represents 90% of oral malignant neoplasms. The search for specific biomarkers for OSCC is a very active field of research contributing to establishing early diagnostic methods and unraveling underlying pathogenic mechanisms. In this work we investigated the salivary metabolites and the metabolic pathways of OSCC aiming find possible biomarkers. Salivary metabolites samples from 27 OSCC patients and 41 control individuals were compared through a gas chromatography coupled to a mass spectrometer (GC-MS) technique. Our results allowed identification of pathways of the malate-aspartate shuttle, the beta-alanine metabolism, and the Warburg effect. The possible salivary biomarkers were identified using the area under receiver-operating curve (AUC) criterion. Twenty-four metabolites were identified with AUC > 0.8. Using the threshold of AUC = 0.9 we find malic acid, maltose, protocatechuic acid, lactose, 2-ketoadipic, and catechol metabolites expressed. We notice that this is the first report of salivary metabolome in South American oral cancer patients, to the best of our knowledge. Our findings regarding these metabolic changes are important in discovering salivary biomarkers of OSCC patients. However, additional work needs to be performed considering larger populations to validate our results.</p> (AU) | |
| FAPESP's process: | 16/08633-0 - TOBACCO SMOKING: FROM MOLECULAR ASPECTS TO SMOKER APPROACHES |
| Grantee: | Janete Dias Almeida |
| Support Opportunities: | Regular Research Grants |