Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands

Author(s)

De Lima-Souza, Reydson Alcides ^{[1, 2]} ; Rodrigues, Natalia de Magalhaes ^[2] ; Scarini, Joao Figueira ^{[1, 2]} ; Sobral Silva, Mario Fernandez ^[3] ; Tincani, Alfio Jose ^[3] ; Abu Egal, Erika Said ^{[4, 2]} ; Altemani, Albina ^[2] ; Mariano, Fernanda Viviane ^[2]

Affiliation

^[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil

^[2] State Univ Campinas UNICAMP, Sch Med Sci, Dept Pathol, Sao Paulo - Brazil

^[3] State Univ Campinas UNICAMP, Sch Med Sci, Dept Surg Head & Neck Surg, Campinas, SP - Brazil

^[4] Univ Utah UU, Sch Med, Dept Pathol, Salt Lake City, UT - USA

• Document type: Journal article
• Source: INTERNATIONAL OPHTHALMOLOGY; NOV 2021.
• Web of Science Citations: 0

Abstract

Purpose To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG). Methods Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1 alpha, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases. Results Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1 alpha in PA samples. Conclusions In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells. (AU)

• FAPESP's process: 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/10788-0 - Morphological and metabolic comparative study between carcinoma ex pleomorphic adenoma of lacrimal and salivar glands
• Grantee: Natália de Magalhães Rodrigues
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate