Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study

Author(s)

Ribeiro, Victor Barbosa ^{[1, 2]} ; Chielli Pedroso, Daiana Cristina ^[1] ; Kogure, Gislaine Satyko ^[1] ; Lopes, Iris Palma ^[1] ; Santana, Barbara Aparecida ^[3] ; Dutra de Souza, Hugo Celso ^[4] ; Ferriani, Rui Alberto ^[1] ; Calado, Rodrigo Tocantins ^[3] ; Miranda Furtado, Cristiana Libardi ^{[1, 5]} ; dos Reis, Rosana Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Gynecol & Obstet, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Fed Inst Sao Paulo, BR-12322030 Jacarei, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14048900 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biomech Med & Rehabil Locomotor Apparat, BR-14048900 Ribeirao Preto, SP - Brazil

^[5] Univ Fed Ceara, Drug Res & Dev Ctr, Postgrad Program Translat Med, BR-60430275 Fortaleza, Ceara - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; v. 18, n. 21 NOV 2021.
• Web of Science Citations: 0

Abstract

Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation with metabolic, hormonal, and anthropometric parameters of PCOS. This randomized controlled clinical trial study included 87 PCOS randomly stratified according to body mass index (BMI) in CAT (n = 28), IAT (n = 29) and non-training control group (CG, n = 30). The exercises were carried out on a treadmill, three times per week for 16 weeks. The participants' anthropometric characteristics and biochemical and hormonal concentrations were measured before and after aerobic training or observation period, as the telomere length that was evaluated using quantitative real-time PCR. Four months of aerobic exercises (CAT or IAT) did not alter telomere length and inflammatory biomarkers in PCOS women. Obesity index as BMI and waist circumference (WC), and inflammatory biomarkers negatively affect telomeres. The hyper-andro-genism measured by testosterone levels was reduced after both exercises (CAT, p \& LE; 0.001; IAT, p = 0.019). In particular, the CAT reduced WC (p = 0.045), hip circumference (p = 0.032), serum cholesterol (p \& LE; 0.001), and low-density lipoprotein (p = 0.030). Whereas, the IAT decreased WC (p = 0.014), waist-to-hip ratio (p = 0.012), free androgen index (FAI) (p = 0.037). WC (p = 0.049) and body fat (p = 0.015) increased in the non-training group while total cholesterol was reduced (p = 0.010). Booth exercises reduced obesity indices and hyperandrogenism on PCOS women without changes in telomere length or inflammatory biomarkers.</p> (AU)

• FAPESP's process: 15/14031-0 - EFFECT OF AEROBIC PHYSICAL TRAINING IN MOLECULAR, METABOLIC, HORMONAL PARAMETERS AND BODY COMPOSITION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: A CLINICAL CONTROLLED TRIAL
• Grantee: Rosana Maria dos Reis
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/11069-9 - ANDROGEN RECEPTOR CAG POLIMORFISM AND TELOMERE LENGTH IN PREMATURE OVARIAN FAILURE
• Grantee: Cristiana Libardi Miranda Furtado
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/17618-3 - DNA mettilation and X chromosome inactivation in women with Polycystic Ovary Syndrome submitted to different physical training protocols
• Grantee: Rosana Maria dos Reis
• Support Opportunities: Regular Research Grants