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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Validation and Application of a Methodology for Quantifying Levels of Parabens in Sports Supplements from Brazil Using Liquid Chromatography-Mass Spectrometry

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Author(s):
Rocha, Bruno A. [1] ; Cesila, Cibele A. [1] ; Martins, Airton C. [2] ; Souza, Marilia C. O. [1] ; Barbosa Jr, Fernando
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Albert Einstein Coll Med, Dept Mol Pharmacol, 1300 Morris Pk Ave, Bronx, NY 10461 - USA
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; DEC 2021.
Web of Science Citations: 0
Abstract

Although parabens have been reported to be used as antimicrobial preservatives in personal care products, pharmaceuticals, and foodstuffs, little is known about the occurrence of these compounds in sports supplements. In this study, a simple, fast and sensitive liquid chromatography tandem mass spectrometry method for simultaneous determination of five commonly used parabens, methyl-, ethyl-, propyl-, butyl-, and benzylparaben in sports supplements was established. The analytical method was validated with the values of parameters being acceptable. The method proved reliable, accurate, and sensitive and was successfully applied for the quantitation of parabens in 85 sports supplements samples. Almost all sports supplements contained at least one of the parabens analyzed, and the total concentrations of five parabens ranged from below the limit of quantification to 145 mu g g-1, with a median value of 0.171 mu g g-1. Ethylparaben and methylparaben were the most frequent paraben analogs found in samples (detection rate > 60%). Propylparaben, butylparaben and benzylparaben are forbidden in food samples, their detection rates were 49.4, 21.2 and 4.7%, respectively. Therefore, our study suggests that Brazilian population may be exposed to estrogenic not allowed parabens and their harmful effects through the intake of sports food supplements. (AU)

FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
Grantee:Fernando Barbosa Júnior
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 21/03633-0 - Development and application of simple and rapid analytical methods for the determination of endocrine disruptors and oxidative stress biomarkers in biological samples for evaluation of exposure of children and pregnant women
Grantee:Bruno Alves Rocha
Support Opportunities: Scholarships in Brazil - Post-Doctoral