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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and evaluation of reparative tricalciumsilicate-ZrO2-Biosilicatecomposites

Full text
Author(s):
Queiroz, Marcela B. [1] ; Torres, Fernanda F. E. [1] ; Rodrigues, Elisandra M. [1] ; Viola, Kennia S. [1] ; Bosso-Martelo, Roberta [2] ; Chavez-Andrade, Gisselle M. [1] ; Souza, Marina T. [3] ; Zanotto, Edgar D. [3] ; Guerreiro-Tanomaru, Juliane M. [1] ; Tanomaru-Filho, Mario [1]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Restorat Dent, Araraquara, SP - Brazil
[2] Bahia Fed Univ UFBA, Sch Dent, Dept Dent, Salvador, BA - Brazil
[3] Fed Univ Sao Carlos UFSCar, CeRTEV Ctr Res Technol & Educ Vitreous Mat, Dept Mat Engn, Vitreous Mat Lab LaMaV, Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 109, n. 4, p. 468-476, APR 2021.
Web of Science Citations: 2
Abstract

Biosilicate is a bioactive glass-ceramic used in medical and dental applications. This study evaluated novel reparative materials composed of pure tricalcium silicate (TCS), 30% zirconium oxide (ZrO2) and 10 or 20% biosilicate, in comparison with Biodentine. Setting time was evaluated based on ISO 6876 standard, radiopacity by radiographic analysis, solubility by mass loss, and pH by using a pH meter. Cytotoxicity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and NR assays. Alkaline phosphatase (ALP) activity and alizarin red were used to evaluate cell bioactivity. Antimicrobial activity was assessed onEnterococcus faecalisby the direct contact test. The data were submitted to analysis of variance (ANOVA)/Tukey; Bonferroni and Kruskal-Wallis, and Dunn tests (alpha= 0.05). The association of Biosilicate with TCS + ZrO(2)had appropriate setting time, radiopacity, and solubility, alkaline pH, and antimicrobial activity. TCS and Biodentine showed higher ALP activity in 14 days than the control (serum-free medium). All cements produced mineralized nodules. In conclusion, Biosilicate + TCS ZrO(2)decreased the setting time and increased the radiopacity in comparison to TCS. Biosilicate + TCS ZrO2 presented lower solubility and higher radiopacity than Biodentine. In addition, these experimental cements promoted antimicrobial activity and mineralization nodules formation, suggesting their potential for clinical use. (AU)

FAPESP's process: 15/03437-6 - Evaluation of reciprocating preparation, root canal filling, and the physicochemical and biological properties of filling and repair materials
Grantee:Mario Tanomaru Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 16/11036-4 - Physicochemical and biological characteristics of new repair materials based on tricalcium silicate and Biosilicate
Grantee:Marcela Borsatto Queiroz
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/00321-0 - Development of new methodologies using micro-CT for evaluation of physicochemical properties of repair materials and endodontic sealers
Grantee:Fernanda Ferrari Esteves Torres Carvalho
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/19049-0 - Evaluation of the root canal treatment procedures, physicochemical and biological properties of tricalcium silicate-based materials
Grantee:Mario Tanomaru Filho
Support Opportunities: Regular Research Grants