| Full text | |
| Author(s): Show less - |
Silva de Lima, Shirlene Telmos
[1, 2]
;
de Souza, William Marciel
[3]
;
Cavalcante, John Washington
[1]
;
Candido, Darlan da Silva
[4]
;
Fumagalli, Marcilio Jorge
[3]
;
Carrera, Jean-Paul
[4, 5]
;
Simoes Mello, Leda Maria
[2]
;
de Carvalho Araujo, Fernanda Montenegro
[2, 6]
;
Cavalcante Ramalho, Izabel Leticia
[2]
;
de Almeida Barreto, Francisca Kalline
[1]
;
de Melo Braga, Deborah Nunes
[7]
;
Simiao, Adriana Rocha
[1]
;
Miranda da Silva, Mayara Jane
[8]
;
Alves Barbosa Oliveira, Rhaquel de Morais
[1]
;
Silva Lima, Clayton Pereira
[8]
;
Lins, Camila de Sousa
[6]
;
Barata, Rafael Ribeiro
[8]
;
Pereira Melo, Marcelo Nunes
[6]
;
Caldas de Souza, Michel Platini
[8]
;
Franco, Luciano Monteiro
[6]
;
Fernandes Tavora, Fabio Rocha
[6]
;
Queiroz Lemos, Daniele Rocha
[6]
;
Morais de Alencar, Carlos Henrique
[1]
;
de Jesus, Ronaldo
[9]
;
Fonseca, Vagner de Souza
[9, 10]
;
Dutra, Leonardo Hermes
[10]
;
de Abreu, Andre Luiz
[10]
;
Lima Araujo, Emerson Luiz
[10]
;
Ribas Freitas, Andre Ricardo
[11]
;
Goncalves Vianez Junior, Joao Lidio da Silva
[8]
;
Pybus, Oliver G.
[4]
;
Moraes Figueiredo, Luiz Tadeu
[3]
;
Faria, Nuno Rodrigues
[4, 12]
;
Teixeira Nunes, Marcio Roberto
[8]
;
de Goes Cavalcanti, Luciano Pamplona
[1]
;
Miyajima, Fabio
[1, 13]
Total Authors: 36
|
| Affiliation: Show less - | [1] Univ Fed Ceara, Fortaleza, Ceara - Brazil
[2] Cent Publ Hlth Lab Ceara State, Fortaleza, Ceara - Brazil
[3] Univ Sao Paulo, Virol Res Ctr, Av Bandeirantes 3900, BR-14090900 Ribeirao Preto, SP - Brazil
[4] Univ Oxford, Dept Zool, Oxford - England
[5] Gorgas Mem Inst Hlth Studies, Dept Res Virol & Biotechnol, Panama City - Panama
[6] Ctr Univ Christus, Fac Med, Fortaleza, Ceara - Brazil
[7] State Hlth Secretariat Ceara, Death Verificat Serv Dr Rocha Furtado, Fortaleza, Ceara - Brazil
[8] Minist Hlth, Evandro Chagas Inst, Ananindeua - Brazil
[9] Univ Fed Minas Gerais, Belo Horizonte, MG - Brazil
[10] Minist Hlth, Brasilia, DF - Brazil
[11] Fac Med Sao Leopoldo Mand, Campinas, SP - Brazil
[12] Imperial Coll London, Dept Infect Dis Epidemiol, London - England
[13] Oswaldo Cruz Fdn Fiocruz, Branch Ceara, Eusebio - Brazil
Total Affiliations: 13
|
| Document type: | Journal article |
| Source: | Clinical Infectious Diseases; v. 73, n. 7, p. E2436-E2443, OCT 1 2021. |
| Web of Science Citations: | 4 |
| Abstract | |
Background. Chikungunya virus (CHIKV) emerged in the Americas in 2013 and has caused approximately 2.1 million cases and >600 deaths. A retrospective investigation was undertaken to describe clinical, epidemiological, and viral genomic features associated with deaths caused by CHIKV in Ceara state, northeast Brazil. Methods. Sera, cerebrospinal fluid (CSF), and tissue samples from 100 fatal cases with suspected arbovirus infection were tested for CHIKV, dengue virus (DENV), and Zika virus (ZIKV). Clinical, epidemiological, and death reports were obtained for patients with confirmed CHIKV infection. Logistic regression analysis was undertaken to identify independent factors associated with risk of death during CHIKV infection. Phylogenetic analysis was conducted using whole genomes from a subset of cases. Results. Sixty-eight fatal cases had CHIKV infection confirmed by reverse-transcription quantitative polymerase chain reaction (52.9%), viral antigen (41.1%), and/or specific immunoglobulin M (63.2%). Co-detection of CHIKV with DENV was found in 22% of fatal cases, ZIKV in 2.9%, and DENV and ZIKV in 1.5%. A total of 39 CHIKV deaths presented with neurological signs and symptoms, and CHIKV-RNA was found in the CSF of 92.3% of these patients. Fatal outcomes were associated with irreversible multiple organ dysfunction syndrome. Patients with diabetes appear to die at a higher frequency during the subacute phase. Genetic analysis showed circulation of 2 CHIKV East-Central-South African (ECSA) lineages in Ceara and revealed no unique virus genomic mutation associated with fatal outcome. Conclusions. The investigation of the largest cross-sectional cohort of CHIKV deaths to date reveals that CHIKV-ECSA strains can cause death in individuals from both risk and nonrisk groups, including young adults. (AU) | |
| FAPESP's process: | 18/00837-1 - Diagnosis of viruses with importance for public health in Brazil by high throughput sequencing and viral genomic studies |
| Grantee: | Luiz Tadeu Moraes Figueiredo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/09383-3 - Study about Flavivirus epitopes with medical importance in Brazil and its antibodies |
| Grantee: | Marcilio Jorge Fumagalli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |