Structural, thermal, electronic, vibrational, magnetic, and cytotoxic properties of chloro(glycinato-N,O)(1,10-phenanthroline-N,N `)-copper(II) trihydrate coordination complex

Author(s)

de Oliveira Neto, J. G. ^[1] ; Filho, J. G. Silva ^[1] ; Bittar, E. M. ^[2] ; Silva, L. M. ^[1] ; de Sousa, F. F. ^{[3, 1]} ; Domingos, H. V. ^[4] ; Costa-Lotufo, L. V. ^[4] ; Reis, A. S. ^[1] ; dos Santos, A. O. ^[1]

Affiliation

^[1] Univ Fed Maranhao, Ctr Ciencias Sociais Saude & Tecnol, BR-65900410 Imperatriz, MA - Brazil

^[2] Ctr Brasileiro Pesquisas Fis, BR-22290180 Rio De Janeiro, RJ - Brazil

^[3] Fed Univ Para, Inst Ciencias Exatas & Nat, BR-66075110 Belem, Para - Brazil

^[4] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508900 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Journal of Inorganic Biochemistry; v. 226, JAN 2022.
• Web of Science Citations: 0

Abstract

Chloro(glycinato-N,O)(1,10-phenanthroline-N,N `)-copper(II) trihydrate complex was synthesized through the slow evaporation method. The crystal's structural, thermal, magnetic, and vibrational properties were obtained by X-ray powder diffraction (XRPD), thermal analyses, magnetization, Raman, and Fourier-transform infrared (FT-IR) spectroscopy. XRPD results showed that the crystalline complex belongs to a monoclinic system (P21/n). Thermal analyses revealed that around 333 K, the material undergoes a thermodynamically irreversible process. Magnetic data showed a paramagnetic behavior with weak ferromagnetic interactions. Moreover, all the Ramanand infrared-active bands were assigned from computational calculations based on the density functional theory (DFT) to analyze intra-molecular vibrational modes. In addition, the cytotoxic assay on colorectal cancer cells was performed to evaluate the antitumor activity of this ternary compound. Therefore, the antineoplastic activity of {[}Cu(1,10-phenanthroline)(glycine)Cl]center dot 3H2O complex in HCT-116 cells was confirmed, showing a potent cytotoxic effect. (AU)

• FAPESP's process: 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds
• Grantee: Leticia Veras Costa Lotufo
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants