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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effects of persistent sleep disturbances during early childhood over adolescent ADHD, and the mediating effect of attention-related executive functions: Data from the 2004 Pelotas Birth Cohort

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Author(s):
Carpena, Marina Xavier [1] ; Matijasevich, Alicia [1, 2] ; de Mola, Christian Loret [3, 4] ; Santos, Ina S. [1, 5] ; Munhoz, Tiago N. [6] ; Tovo-Rodrigues, Luciana [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS - Brazil
[2] Univ Sao Paulo, Dept Prevent Med, Fac Med FMUSP, Sao Paulo - Brazil
[3] Fundacao Univ Fed Rio Grande, Programa Posgrad Saude Publ, Rio Grande, RS - Brazil
[4] Univ Fed Rio Grande FURG, Grp Pesquisa & Inovacao Saude, Rio Grande, RS - Brazil
[5] Pontifical Univ Catolica Rio Grande do Sul, Postgrad Program Pediat Child Hlth, Porto Alegre, RS - Brazil
[6] Univ Fed Pelotas, Fac Psychol, Pelotas, RS - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Journal of Affective Disorders; v. 296, p. 175-182, JAN 1 2022.
Web of Science Citations: 0
Abstract

Objective: Investigate effects of persistent sleep disturbances during early childhood over ADHD during the adolescence, and the potential attention-related executive functions mediating this effect. Methods: We used data from the 2004 Pelotas Birth Cohort. Children's Sleep disturbances were reported by their mothers at 12, 24, and 48 months of age, whereas the Test-of-Everyday-Attention-for-Children (TEA-Ch) and the Development and Well Being Assessment (DAWBA) were applied at 11 years of age to evaluate attention-related executive functions and ADHD, respectively. Persistent sleep problems were defined as reporting have two or more points of difficulty to sleep, nightmares, restless sleeps, and/or <10h/24h sleep duration. Logistic regression and mediation models were used, adjusting for maternal and child sociodemographic, behavior and health related variables. Results: The highest prevalence of adolescent ADHD (15.4%) was on the group who reported having nightmares at 2,4 and 6 years. In adjusted models, we observed an odd of ADHD in the adolescence 2.26 higher in those who reported persistent nightmares (CI95% 1.33, 4.01) compared to those reported transitory or no nightmares. Persistent difficulty to sleep (OR=1.74 CI95% 1.13, 2.66) and restless sleep (OR=1.80, CI95% 1.23, 2.64) during childhood also increased ADHD odds at 11 years. No indirect effect through attention related executive functions was found using mediating models. Discussion: Persistent early sleep disturbances may increase odds of ADHD among adolescents and could be consider as early marker of such disorder, specially nightmares problems. These effects were not mediated by attention-related executive functions. Nevertheless, we had 75% of cohort inception response. (AU)

FAPESP's process: 14/13864-6 - Mental disorders, substance use and executive functions in early adolescence in a birth cohort
Grantee:Alicia Matijasevich Manitto
Support Opportunities: Regular Research Grants