Mental disorders, substance use and executive functions in early adolescence in a birth cohort

• Grant number: 14/13864-6
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2015
• End date: January 31, 2017
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Alicia Matijasevich Manitto
• Grantee: Alicia Matijasevich Manitto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Aluisio Jardim Dornellas de Barros ; Iná da Silva dos Santos

Abstract

Mental disorders and substance use are among the leading causes of years lost due to disability. These problems often begin in the adolescence, persist throughout the life cycle, are associated with a wide range of adverse outcomes in adulthood and may even jeopardize the well-being of future generations. Environmental, genetic, biological and behavioral determinants have been investigated in order to understand the etiology and natural history of mental disorders and substance use among population groups from high-income countries, but little research has been carried out in low- and middle-income countries. The main objectives of the present project are: (1) to assess the frequency and risk factors of mental disorders and tobacco and alcohol consumption in the early adolescence (age 11 years); (2) to assess impairment of executive functions among individuals with mental disorders and among those who reported tobacco and alcohol consumption and (3) to elucidate the mediator role of the executive functions in the associations between early risk factors and mental and substance use disorders. We will evaluate approximately 3600 adolescents from a Brazilian population-based birth cohort study. Cohort members have been followed-up with high response rates at regular intervals since birth. The results of this project will contribute to outline recommendations and develop preventive strategies to reduce mental health problems in adolescence and their medical and social consequences in adulthood. (AU)

Scientific publications

(34)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

LA MAISON, CAROLINA; MARUYAMA, JESSICA M.; MUNHOZ, TIAGO N.; SANTOS, INA S.; DO AMARAL, MARIANA R.; ANSELMI, LUCIANA; BARROS, FERNANDO C.; PASTOR-VALERO, MARIA; MATIJASEVICH, ALICIA. Continuity of psychiatric disorders between 6 and 11 years of age in the 2004 Pelotas Birth Cohort. Revista Brasileira de Psiquiatria, v. 42, n. 5, p. 496-502, SEP-OCT 2020. (14/13864-6, 17/22723-5)

MARTINS-SILVA, THAIS; BAUER, ANDREAS; MATIJASEVICH, ALICIA; MUNHOZ, TIAGO N.; BARROS, ALUISIO J. D.; SANTOS, INA S.; TOVO-RODRIGUES, LUCIANA; MURRAY, JOSEPH. Early risk factors for conduct problem trajectories from childhood to adolescence: the 2004 Pelotas (BRAZIL) Birth Cohort. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. N/A, p. 15-pg., 2023-04-25. (20/07730-8, 14/13864-6)

MATIJASEVICH, ALICIA; PEARSON, REBECCA M.; DE MOLA, CHRISTIAN LORET; MARUYAMA, JESSICA MAYUMI; LA MAISON, CAROLINA; MUNHOZ, TIAGO N.; BARROS, FERNANDO C.; SANTOS, INA S.; BARROS, ALUISIO J. D.. Early child stimulation and attention-related executive functions at 11 years: 2004 Pelotas birth cohort study. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 29, n. 9, NOV 2019. (17/22723-5, 14/13864-6)

TOVO-RODRIGUES, LUCIANA; SCHNEIDER, BRUNA CELESTINO; MARTINS-SILVA, THAIS; DEL-PONTE, BIANCA; DE MOLA, CHRISTIAN LORET; SCHULER-FACCINI, LAVINIA; LUIZ VIANNA, FERNANDA SALES; MUNHOZ, TIAGO N.; ENTIAUSPE, LUDMILA; SILVEIRA, MARIANGELA FREITAS; et al. Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort. BMC Psychiatry, v. 18, NOV 20 2018. (14/13864-6)

AZEREDO, CATARINA MACHADO; SANTOS, INA S.; BARROS, ALUISIO J. D.; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA. Maternal depression and bullying victimization among adolescents: Results from the 2004 Pelotas cohort study. DEPRESSION AND ANXIETY, v. 34, n. 10, p. 897-907, OCT 2017. (14/13864-6)

JESSICA MAYUMI MARUYAMA; LUCIANA TOVO-RODRIGUES; INÁ S. SANTOS; JOSEPH MURRAY; ALICIA MATIJASEVICH. Changes and predictors of adolescent emotion regulation, self-esteem, and locus of control during the COVID-19 pandemic: 2004 Pelotas Birth Cohort. Revista Brasileira de Psiquiatria, v. 45, n. 5, p. 389-396, 2023-11-17. (14/13864-6, 17/22723-5, 20/07730-8)

CARPENA, MARINA XAVIER; MUNHOZ, TIAGO N.; XAVIER, MARIANA OTERO; ROHDE, LUIS AUGUSTO; SANTOS, INA S.; DEL-PONTE, BIANCA; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA; TOVO-RODRIGUES, LUCIANA. The Role of Sleep Duration and Sleep Problems During Childhood in the Development of ADHD in Adolescence: Findings From a Population-Based Birth Cohort. JOURNAL OF ATTENTION DISORDERS, v. 24, n. 4, p. 11-pg., 2019-10-16. (14/13864-6)

TOVO-RODRIGUES, LUCIANA; CAMERINI, LAISA; MARTINS-SILVA, THAIS; CARPENA, MARINA XAVIER; BONILLA, CAROLINA; OLIVEIRA, ISABEL OLIVEIRA; DE PAULA, CRISTIANE SILVESTRE; MURRAY, JOSEPH; BARROS, ALUISIO J. D.; SANTOS, INA S.; et al. Gene - maltreatment interplay in adult ADHD symptoms: main role of a gene-environment correlation effect in a Brazilian population longitudinal study. MOLECULAR PSYCHIATRY, v. 29, n. 11, p. 10-pg., 2024-05-14. (14/13864-6, 20/07730-8)

MARUYAMA, JESSICA MAYUMI; TOVO-RODRIGUES, LUCIANA; SANTOS, INA S.; MURRAY, JOSEPH; MATIJASEVICH, ALICIA. Adolescent Mental Health Before and During COVID-19: Longitudinal Evidence From the 2004 Pelotas Birth Cohort in Brazil. JOURNAL OF ADOLESCENT HEALTH, v. 74, n. 4, p. 10-pg., 2024-03-20. (17/22723-5, 14/13864-6, 20/07730-8)

ECHEVARRIA, PRISCILA; DEL-PONTE, BIANCA; TOVO-RODRIGUES, LUCIANA; MATIJASEVICH, ALICIA; HALAL, CAMILA S.; SANTOS, INDA S.. Screen use and sleep duration and quality at 15 years old: Cohort study. SLEEP MEDICINE-X, v. 5, p. 9-pg., 2023-12-01. (20/07730-8, 14/13864-6)

MARUYAMA, JESSICA MAYUMI; SANTOS, INA S.; MUNHOZ, TIAGO NEUENFELD; MATIJASEVICH, ALICIA. Maternal depression trajectories and offspring positive attributes and social aptitudes at early adolescence: 2004 Pelotas birth cohort. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 30, n. 12, p. 1939-1948, DEC 2021. (17/22723-5, 14/13864-6)

LA MAISON, CAROLINA; MARUYAMA, JESSICA M.; MUNHOZ, TIAGO N.; SANTOS, INA S.; DO AMARAL, MARIANA R.; ANSELMI, LUCIANA; BARROS, FERNANDO C.; PASTOR-VALERO, MARIA; MATIJASEVICH, ALICIA. Continuity of psychiatric disorders between 6 and 11 years of age in the 2004 Pelotas Birth Cohort. Revista Brasileira de Psiquiatria, v. 42, n. 5, p. 7-pg., 2020-09-01. (17/22723-5, 14/13864-6)

MARUYAMA, JESSICA MAYUMI; VALENTE, JULIANA Y.; TOVO-RODRIGUES, LUCIANA; SANTOS, INA S.; BARROS, ALUISIO J. D.; MUNHOZ, TIAGO N.; BARROS, FERNANDO C.; MURRAY, JOSEPH; MATIJASEVICH, ALICIA. Maternal depression trajectories in childhood, subsequent maltreatment, and adolescent emotion regulation and self-esteem: the 2004 Pelotas birth cohort. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. N/A, p. 11-pg., 2022-06-22. (17/22723-5, 20/07730-8, 14/13864-6)

BOZZINI, ANA BEATRIZ; MARUYAMA, JESSICA MAYUMI; MUNHOZ, TIAGO N.; BARROS, ALUISIO J. D.; BARROS, FERNANDO C.; SANTOS, INA S.; MATIJASEVICH, ALICIA. Trajectories of maternal depressive symptoms and offspring's risk behavior in early adolescence: data from the 2004 Pelotas birth cohort study. BMC Psychiatry, v. 21, n. 1, JAN 7 2021. (17/22723-5, 14/13864-6)

MARUYAMA, JESSICA MAYUMI; SANTOS, INA S.; MUNHOZ, TIAGO NEUENFELD; MATIJASEVICH, ALICIA. Maternal depression trajectories and offspring positive attributes and social aptitudes at early adolescence: 2004 Pelotas birth cohort. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, OCT 2020. (14/13864-6, 17/22723-5)

CARPENA, MARINA XAVIER; MUNHOZ, TIAGO N.; XAVIER, MARIANA OTERO; ROHDE, LUIS AUGUSTO; SANTOS, INA S.; DEL-PONTE, BIANCA; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA; TOVO-RODRIGUES, LUCIANA. The Role of Sleep Duration and Sleep Problems During Childhood in the Development of ADHD in Adolescence: Findings From a Population-Based Birth Cohort. JOURNAL OF ATTENTION DISORDERS, v. 24, n. 4, SI, OCT 2019. (14/13864-6)

AZEREDO, CATARINA MACHADO; CORTESE, MARIANNA; COSTA, CAROLINE DOS SANTOS; BJORNEVIK, KJETIL; BARROS, ALUISIO J. D.; BARROS, FERNANDO C.; SANTOS, INA S.; MATIJASEVICH, ALICIA. Ultra-processed food consumption during childhood and asthma in adolescence: Data from the 2004 Pelotas birth cohort study. PEDIATRIC ALLERGY AND IMMUNOLOGY, v. 31, n. 1, OCT 2019. (14/13864-6)

DEL-PONTE, BIANCA; ANSELMI, LUCIANA; ASSUNCAO, MARIA CECILIA F.; TOVO-RODRIGUES, LUCIANA; MUNHOZ, TIAGO N.; MATIJASEVICH, ALICIA; ROHDE, LUIS AUGUSTO; SANTOS, INA S.. Sugar consumption and attention-deficit/hyperactivity disorder (ADHD): A birth cohort study. Journal of Affective Disorders, v. 243, p. 290-296, JAN 15 2019. (14/13864-6)

MARUYAMA, JESSICA MAYUMI; PASTOR-VALERO, MARIA; SANTOS, INA S.; MUNHOZ, TIAGO N.; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA. Impact of maternal depression trajectories on offspring socioemotional competences at age 11: 2004 Pelotas Birth Cohort. Journal of Affective Disorders, v. 253, p. 8-17, JUN 15 2019. (14/13864-6, 17/22723-5)

CARPENA, MARINA XAVIER; MATIJASEVICH, ALICIA; DE MOLA, CHRISTIAN LORET; SANTOS, INA S.; MUNHOZ, TIAGO N.; TOVO-RODRIGUES, LUCIANA. The effects of persistent sleep disturbances during early childhood over adolescent ADHD, and the mediating effect of attention-related executive functions: Data from the 2004 Pelotas Birth Cohort. Journal of Affective Disorders, v. 296, p. 175-182, JAN 1 2022. (14/13864-6)

ZIEBOLD, CAROLINA; PAULA, CRISTIANE SILVESTRE; SANTOS, INA S.; BARROS, FERNANDO C.; MUNHOZ, TIAGO N.; LUND, CRICK; MCDAID, DAVID; ARAYA, RICARDO; BAUER, ANNETTE; GARMAN, EMILY; et al. onditional cash transfers and adolescent mental health in Brazil: Evidence from the 2004 Pelotas Birth Cohor. OURNAL OF GLOBAL HEALT, v. 11, 2021. (14/13864-6)

BAUER, ANDREAS; FAIRCHILD, GRAEME; HALLIGAN, SARAH L.; HAMMERTON, GEMMA; MURRAY, JOSEPH; SANTOS, INA S.; MUNHOZ, TIAGO N.; BARROS, ALUISIO J. D.; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA. Harsh parenting and child conduct and emotional problems: parent- and child-effects in the 2004 Pelotas Birth Cohort. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 31, n. 8, p. 11-pg., 2021-03-18. (14/13864-6)

LA MAISON, CAROLINA; MUNHOZ, TIAGO N.; SANTOS, INA S.; ANSELMI, LUCIANA; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA. Prevalence and risk factors of psychiatric disorders in early adolescence: 2004 Pelotas (Brazil) birth cohort. Social Psychiatry and Psychiatric Epidemiology, v. 53, n. 7, p. 685-697, JUL 2018. (14/13864-6)

SCHMIDT DA SILVA, VERA LUCIA; ARAUJO DE FRANCA, GIOVANNY VINICIUS; MUNHOZ, TYAGO N.; SANTOS, INA S.; BARROS, ALUISIO J. D.; BARROS, FERNANDO C.; MATIJASEVICH, ALICIA. Hospitalization in the first years of life and development of psychiatric disorders at age 6 and 11: a birth cohort study in Brazil. Cadernos de Saúde Pública, v. 34, n. 5, 2018. (14/13864-6)

DEL-PONTE, BIANCA; SANTOS, INA S.; TOVO-RODRIGUES, LUCIANA; ANSELMI, LUCIANA; MUNHOZ, TIAGO N.; MATIJASEVICH, ALICIA. Caffeine consumption during pregnancy and ADHD at the age of 11 years: a birth cohort study. BMJ OPEN, v. 6, n. 12, 2016. (14/13864-6)

QUINTE, GABRIELA CALLO; MUNHOZ, TIAGO N.; MATIJASEVICH, ALICIA; SANTOS, INA S.. Maternal pre-pregnancy body mass index and mental health problems in early adolescents from the 2004 Pelotas birth cohort. SCIENTIFIC REPORTS, v. 12, n. 1, p. 7-pg., 2022-08-24. (14/13864-6)

MARIANA OTERO XAVIER; JESSICA MAYUMI MARUYAMA; INÁ S. SANTOS; LUCIANA TOVO-RODRIGUES; ALUÍSIO J. D. BARROS; ALICIA MATIJASEVICH. Changes of adolescent sleep patterns during the COVID-19 pandemic. Revista de Saúde Pública, v. 58, 2024-07-05. (14/13864-6, 17/22723-5, 20/07730-8)

JÚLIA DE SOUZA RODRIGUES; ALICIA MATIJASEVICH; LUCIANA TOVO-RODRIGUES; TIAGO N. MUNHOZ; INÁ S. SANTOS; MARIA PASTOR-VALERO. Risk factors for executive function impairment in adolescence: an analysis of data from the 2004 Pelotas Birth Cohort study. Revista Brasileira de Psiquiatria, v. 45, n. 6, p. 470-481, 2024-02-12. (14/13864-6, 20/13425-3, 20/07730-8)

XAVIER, MARIANA OTERO; TOVO-RODRIGUES, LUCIANA; SANTOS, INA S.; MURRAY, JOSEPH; MARUYAMA, JESSICA MAYUMI; MATIJASEVICH, ALICIA. Harsh parenting trajectories from childhood through adolescence and socioemotional competences at age 18: 2004 Pelotas Birth Cohort Study. Journal of Affective Disorders, v. 366, p. 11-pg., 2024-09-04. (14/13864-6, 20/07730-8, 23/12905-0)

SANCHEZ-LUQUEZ, KAREN Y.; CARPENA, MARINA XAVIER; KARAM, SIMONE M.; MARTINS-SILVA, THAIS; BARROS, FERNANDO C.; DE OLIVEIRA, ISABEL O.; SANTOS, INA S.; BARROS, ALUISIO J. D.; MATIJASEVICH, ALICIA; TOVO-RODRIGUES, LUCIANA. Evaluation of genomic factors and early childhood stimulation on intelligence in children from a Brazilian birth cohort: The primary role of independent factors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 131, p. 8-pg., 2024-01-11. (14/13864-6, 20/07730-8)

MATIJASEVICH, A.; MAYUMI MARUYAMA, J.; TOVO-RODRIGUES, L.; MURRAY, J.; SANTOS, I. S.. ADOLESCENT MENTAL HEALTH BEFORE AND DURING COVID-19: LONGITUDINAL EVIDENCE FROM THE 2004 PELOTAS BIRTH COHORT IN BRAZIL. GACETA SANITARIA, v. 37, p. 1-pg., 2023-09-01. (14/13864-6)

MARUYAMA, JESSICA MAYUMI; BAUER, ANDREAS; HAMMERTON, GEMMA; HALLIGAN, SARAH L.; SANTOS, INA S.; MUNHOZ, TIAGO N.; BARROS, ALUISIO J. D.; BARROS, FERNANDO C.; FAIRCHILD, GRAEME; MATIJASEVICH, ALICIA. Pathways from maternal depression to child resilience: Socioeconomic, family, and individual factors in the 2004 Pelotas (Brazil) birth cohort. JCPP ADVANCES, v. 3, n. 4, p. 10-pg., 2023-12-01. (17/22723-5, 14/13864-6)

BAILEY, MEGAN; FAIRCHILD, GRAEME; HAMMERTON, GEMMA; SANTOS, INA S.; TOVO-RODRIGUES, LUCIANA; MURRAY, JOSEPH; MATIJASEVICH, ALICIA; HALLIGAN, SARAH L.. Childhood trauma, adolescent risk behaviours and cardiovascular health indices in the 2004 Pelotas Birth Cohort. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. 66, n. 11, p. 11-pg., 2025-04-30. (14/13864-6, 20/07730-8, 23/12905-0)

ALICIA MATIJASEVICH; JESSICA MAYUMI MARUYAMA; LUCIANA TOVO-RODRIGUES; INÁ S. SANTOS. Maternal depressive symptoms trajectories and harsh parenting: the mediating role of maternal quality of life in the 2004 Pelotas Birth Cohort. Revista Brasileira de Psiquiatria, v. 47, 2025-03-03. (14/13864-6)