| Full text | |
| Author(s): |
Carvalho, Julia Ribeiro Garcia
[1]
;
Conde, Gabriel
[1]
;
Antonioli, Marina Lansarini
[1]
;
Santana, Clarissa Helena
[2]
;
Littiere, Thayssa Oliveira
[1]
;
Dias, Paula Patrocinio
[3]
;
Chinelatto, Marcelo Aparecido
[3]
;
Canola, Paulo Alescio
[1]
;
Zara, Fernando Jose.
[1]
;
Ferraz, Guilherme Camargo
[1]
Total Authors: 10
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Sch Agr & Vet Sci FCAV, BR-14884900 Jaboticabal, SP - Brazil
[2] Fed Univ Minas Gerais UFMG, Vet Sch, BR-31270901 Belo Horizonte, MG - Brazil
[3] Univ Sao Paulo, Sao Carlos Sch Engn EESC, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Molecules; v. 26, n. 23 DEC 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
In horses, there is an increasing interest in developing long-lasting drug formulations, with biopolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocompatibility and biodegradation of PLA, prepared by hot pressing at 180 degrees C. Six samples were implanted subcutaneously on the lateral surface of the neck of one horse. The polymers remained implanted for 24 to 57 weeks. Physical examination, plasma fibrinogen, and the mechanical nociceptive threshold (MNT) were performed. After 24, 28, 34, 38, and 57 weeks, the materials were removed for histochemical analysis using hematoxylin-eosin and scanning electron microscopy (SEM). There were no essential clinical changes. MNT decreased after the implantation procedure, returning to normal after 48 h. A foreign body response was observed by histopathologic evaluation up to 38 weeks. At 57 weeks, no polymer or fibrotic capsules were identified. SEM showed surface roughness suggesting a biodegradation process, with an increase in the median pore diameter. As in the histopathological evaluation, it was not possible to detect the polymer 57 weeks after implantation. PLA showed biocompatible degradation and these findings may contribute to future research in the biomedical area. (AU) | |
| FAPESP's process: | 19/16779-3 - Study of the efficiency and safety of the vibratory platform as an adjuvant in equine training |
| Grantee: | Júlia Ribeiro Garcia de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/10959-4 - Applicability of biopolymers implanted in horses |
| Grantee: | Júlia Ribeiro Garcia de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 15/26738-1 - Behavior and muscle biomarkers in rats submitted to overtraining syndrome |
| Grantee: | Guilherme de Camargo Ferraz |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/13685-5 - Integrative analysis of the Brazilian fauna of decapod crustaceans: taxonomy, phylogenetic systematics, spermiotaxonomy, morphology of post-embryonic development, ecology and conservation |
| Grantee: | Fernando Luis Medina Mantelatto |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |