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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

UDCA receptors and their role on pancreatic beta cell

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Author(s):
Rosa, Lucas Rodolfo de Oliveira [1] ; Vettorazzi, Jean Franciesco [2] ; Zangerolamo, Lucas [1] ; Carneiro, Everardo Magalhaes [1] ; Barbosa, Helena Cristina de Lima [1]
Total Authors: 5
Affiliation:
[1] Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
[2] Educ Union Cascavel Univel, Cascavel - Brazil
Total Affiliations: 2
Document type: Review article
Source: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY; v. 167, p. 26-31, DEC 2021.
Web of Science Citations: 1
Abstract

Bile acids have received increasing attention over the past years as their multiple alternative roles became clearer. Tauroursodeoxycholic Acid (TUDCA) in specific has generated special interest due to its ability to promote pancreatic survival and function, as well as reduce endoplasmic reticulum stress. However, there are few studies explaining the molecular mechanisms behind TUDCA's beneficial actions on pancreatic beta cells. In this review, we decided to review the literature in order to craft a primer for researchers on what is known about TUDCA's receptors and the molecular pathways involved in this bile acid's function in the endocrine pancreas. We review the studies that focused on G protein-coupled bile acid receptor (TGR5), Sphingosine-1-phosphate receptor 2 (S1PR2) and alpha 5 beta 1 Integrin function in pancreatic cells. Our hope is to provide a basis for future studies to expand upon, especially considering the current lack of studies focusing on the importance of these receptors, either through TUDCA signaling or other signaling molecules. (C) 2021 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 19/23951-7 - Focal adhesion kinase (FAK) as an element of the mechanisms of action of tauroursodeoxycholic bile acid (TUDCA)
Grantee:Lucas Rodolfo de Oliveira Rosa
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/14993-9 - Type 3 muscarinic receptor activation and association with ADP-rybosilation factor 1 and 6 on the pancreatic beta-cell function: downstream signalling pathways, islet arquitecture and insulin secretion
Grantee:Helena Cristina de Lima Barbosa
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 15/12611-0 - Molecular mechanisms involved in pancreatic beta cell disfunction and dead in diabetes mellitus: strategies for the inhibition of these processes and restoration of the insular mass
Grantee:Antonio Carlos Boschiero
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/06363-1 - Therapeutic potential of GHRH and metformin on pancreatic beta cell function against endoplasmic reticulum stress and type 2 diabetes mellitus progress
Grantee:Helena Cristina de Lima Barbosa
Support Opportunities: Regular Research Grants