The Role of ANP Level Response in Interdisciplinary Weight Loss Therapy on Cardiometabolic Risk and Body Composition in Adolescents with Obesity

Author(s)

Ana Claudia Pelissari Kravchychyn ^[1] ; Raquel Munhoz da Silveira Campos ^[2] ; Yasmin Alaby Martins Ferreira ^[3] ; Sofia Emanuelle de Castro Ferreira Vicente ; Flávia Campos Corgosinho ^[5] ; Lila Missae Oyama ^[6] ; Valter Tadeu Boldarine ^[7] ; Lian Tock ^[8] ; David Thivel ^[9] ; Ana Raimunda Dâmaso ^[10]

Affiliation

^[1] Universidade Federal de São Paulo. Programa de Pós-graduação em Nutrição - Brasil

^[2] Universidade Federal de São Paulo. Departamento de Biociências. Programa de Pós Graduação Interdisciplinar em Ciências da Saúde - Brasil

^[3] Universidade Federal de São Paulo. Programa de Pós-graduação em Nutrição - Brasil

^[5] Universidade Federal de Goiás - Brasil

^[6] Universidade Federal de São Paulo. Programa de Pós-graduação em Nutrição - Brasil

^[7] Universidade Federal de São Paulo. Programa de Pós-graduação em Nutrição - Brasil

^[8] Universidade Federal de São Paulo. Programa de Pós-graduação em Nutrição - Brasil

^[9] Université Clermont Auvergne - França

^[10] Universidade Federal de São Paulo. Programa de Pós-graduação em Nutrição - Brasil

• Document type: Journal article
• Source: Arquivos Brasileiros de Cardiologia; v. 118, n. 1, p. 33-40, 2022-02-21.

Abstract

Abstract Background The action of atrial natriuretic peptide (ANP) on natriuresis, diuresis and vasodilatation, insulin resistance, liver, kidney, and adipose tissue may contribute to the healthy metabolic and cardiovascular development. Even though the circulating level of ANP is reduced in patients with obesity, its response to weight loss remains poorly explored in pediatric populations. Objective To evaluate the effects of ANP variations in response to interdisciplinary weight loss intervention on metabolic syndrome (MetS) and cardiometabolic risks in adolescents with obesity. Methods 73 adolescents with obesity attended a 20-week clinical interdisciplinary weight loss therapy including clinical, nutritional, psychological and exercise training approach. Body composition, biochemical analyses and blood pressure were evaluated. MetS was classified according to the International Diabetes Federation (IDF) (2007). After the treatment, volunteers were divided according to Increasing (n=31) or Decreasing (n=19) ANP plasma levels. Results Both groups present significant reduction of body weight, Body Mass Index (BMI), waist, neck and hip circumferences (WC, NC and HC, respectively) and increasing fat-free mass (FFM). Interestingly, a significant reduction in body fat, TG/HDL-c ratio and MetS prevalence (from 23% to 6%) was observed in the Increased ANP group only. Conclusion This study suggests that an increase in ANP serum levels after weight loss therapy could be associated with improvements in cardiometabolic risks and the reduced prevalence of MetS in adolescents with obesity. (AU)

• FAPESP's process: 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women
• Grantee: Raquel Munhoz da Silveira Campos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08522-6 - New therapeutic perspectives in obesity
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants