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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Silent circulation of Chikungunya virus among pregnant women and newborns in the Western Brazilian Amazon before the first outbreak of chikungunya fever

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Author(s):
Kelly Aparecida Kanunfre ; Mussya Cisotto Rocha ; Maíra Barreto Malta ; Rodrigo Medeiros de Souza [4] ; Marcia Caldas Castro [5] ; Silvia Beatriz Boscardin [6] ; Higo Fernando Santos Souza [7] ; Steven S. Witkin ; Marly Augusto Cardoso [9] ; Thelma Suely Okay
Total Authors: 10
Document type: Journal article
Source: Revista do Instituto de Medicina Tropical de São Paulo; v. 64, 2022-04-04.
Abstract

ABSTRACT The prevalence of immunity to Chikungunya virus (CHIKV) in pregnant women and newborns in the Western Brazilian Amazon was assessed at a time when previous studies did not report chikungunya fever in the area. In 435 asymptomatic pregnant women and 642 healthy unrelated newborns, the presence of IgM and IgG antibodies to CHIKV were determined by a commercial ELISA. All participants were negative to IgM anti-CHIKV. Anti-CHIKV IgG was identified in 41 (9.4%) pregnant women and 66 (10.3%) newborns. The presence of anti-CHIKV IgG was positively associated with the lowest socioeconomic status in pregnant women (OR 2.54, 95% CI 1.15-5.62, p=0.021) and in the newborns’ mothers (OR 5.10, 95% CI 2.15-12.09, p< 0.001). Anti-CHIKV IgG was also associated with maternal age in both, the pregnant women (OR 1.06, 95% CI 1.00-1.11, p=0.037) and the newborns’mothers (OR 1.08, 95% CI 1.03-1.12, p=0.001). Pregnancy outcomes in which the mother or the newborn was anti-CHIKV IgG positive proceeded normally. Negative CHIKV serology was associated with being positive for DENV antibodies and having had malaria during pregnancy. These findings showed that there was already a silent circulation of CHIKV in this Amazon region before the first outbreak of chikungunya fever. Furthermore, seropositivity for CHIKV was surprisingly frequent (10%) in both, pregnant women and newborns, affecting mainly low-income women. (AU)

FAPESP's process: 16/00270-6 - MINA study - Maternal and child health in Acre: birth cohort in the Western Brazilian Amazon
Grantee:Marly Augusto Cardoso
Support Opportunities: Research Projects - Thematic Grants