| Full text | |
| Author(s): Show less - |
R. Gorjão
[1]
;
S.M. Hirabara
[2]
;
L.N. Masi
[3]
;
T.D.A. Serdan
;
R.B. Gritte
[5]
;
E. Hatanaka
[6]
;
T. Souza-Siqueira
[7]
;
A.C. Pithon-Curi
[8]
;
T.M. de Lima
[9]
;
T.C. Pithon-Curi
[10]
;
J.F.M. Marchini
[11]
;
M.C.C. Machado
[12]
;
H.P. Souza
[13]
;
R. Curi
Total Authors: 14
|
| Affiliation: Show less - | [1] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[2] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[3] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[5] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[6] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[7] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[8] Universidade de São Paulo. Laboratório de Emergências Clínicas (LIM-51), Faculdade de Medicina - Brasil
[9] Universidade de São Paulo. Laboratório de Emergências Clínicas (LIM-51), Faculdade de Medicina - Brasil
[10] Universidade Cruzeiro do Sul. Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde - Brasil
[11] Universidade de São Paulo. Laboratório de Emergências Clínicas (LIM-51), Faculdade de Medicina - Brasil
[12] Universidade de São Paulo. Laboratório de Emergências Clínicas (LIM-51), Faculdade de Medicina - Brasil
[13] Universidade de São Paulo. Laboratório de Emergências Clínicas (LIM-51), Faculdade de Medicina - Brasil
Total Affiliations: 14
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 55, 2022-06-22. |
| Abstract | |
Diabetes is associated with a worse prognosis and a high risk of morbidity and mortality in COVID-19 patients. We aimed to evaluate the main factors involved in the poor prognosis in diabetic patients. A total of 984 patients diagnosed with COVID-19 admitted to the hospital were included in this study. Patients were first divided into type-2 diabetic (DM+) and non-diabetic (DM–) groups. The participants were analyzed based on the National Early Warning Score (NEWS) and on the Quick-Sequential Organ Failure Assessment (qSOFA) to find the best prognostic risk score for our study. The DM+ and DM– groups were divided into non-severe and severe groups. Comparative and correlative analyses were used to identify the physiological parameters that could be employed for creating a potential risk indicator for DM+ COVID-19 patients. We found a poorer prognosis for the DM+ COVID-19 patients with a higher ICU admission rate, mechanical ventilation rate, vasopressor use, dialysis, and longer treatment times compared with the DM– group. DM+ COVID-19 patients had increased plasma glucose, lactate, age, urea, NEWS, and D-dimer levels, herein referred to as the GLAUND set, and worse prognosis and outcomes when compared with infected DM– patients. The NEWS score was a better indicator for assessing COVID-19 severity in diabetic patients than the q-SOFA score. In conclusion, diabetic COVID-19 patients should be assessed with the NEWS score and GLAUND set for determining their prognosis COVID-19 prognosis. (AU) | |
| FAPESP's process: | 20/04738-8 - Patients with Severe Acute Respiratory Syndrome due to COVID-19 in an emergency department |
| Grantee: | Heraldo Possolo de Souza |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/07283-1 - Effects of leptin on lymphocyte differentiation and metabolism |
| Grantee: | Renata Gorjao |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/09868-7 - Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise |
| Grantee: | Rui Curi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/08624-0 - Post-COVID Sydrom: immunological sequelae after COVID-19 infection |
| Grantee: | Marcel Cerqueira Cesar Machado |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/25892-8 - Reversal of spontaneous Type 2 Diabetes by bone marrow transplant |
| Grantee: | Laureane Nunes Masi |
| Support Opportunities: | Regular Research Grants |