| Full text | |
| Author(s): |
Lazarini-Lopes, Willian
;
Silva-Cardoso, Gleice Kelli
;
Andrade Leite-Panissi, Christie Ramos
;
Garcia-Cairasco, Norberto
Total Authors: 4
|
| Document type: | Journal article |
| Source: | BIOMEDICINES; v. 10, n. 2, p. 19-pg., 2022-02-01. |
| Abstract | |
Epilepsies are neurological disorders characterized by chronic seizures and their related neuropsychiatric comorbidities, such as anxiety. The Transient Receptor Potential Vanilloid type-1 (TRPV1) channel has been implicated in the modulation of seizures and anxiety-like behaviors in preclinical models. Here, we investigated the impact of chronic epileptic seizures in anxiety-like behavior and TRPV1 channels expression in a genetic model of epilepsy, the Wistar Audiogenic Rat (WAR) strain. WARs were submitted to audiogenic kindling (AK), a preclinical model of temporal lobe epilepsy (TLE) and behavioral tests were performed in the open-field (OF), and light-dark box (LDB) tests 24 h after AK. WARs displayed increased anxiety-like behavior and TRPV1R expression in the hippocampal CA1 area and basolateral amygdala nucleus (BLA) when compared to control Wistar rats. Chronic seizures increased anxiety-like behaviors and TRPV1 and FosB expression in limbic and brainstem structures involved with epilepsy and anxiety comorbidity, such as the hippocampus, superior colliculus, and periaqueductal gray matter. Therefore, these results highlight previously unrecognized alterations in TRPV1 expression in brain structures involved with TLE and anxiogenic-like behaviors in a genetic model of epilepsy, the WAR strain, supporting an important role of TRPV1 in the modulation of neurological disorders and associated neuropsychiatric comorbidities. (AU) | |
| FAPESP's process: | 18/06877-5 - Systemic treatment with canabidiol in a neuropathic pain model: evaluation of the sensorial-discriminative and emotional-motivacional components pain sensitivity |
| Grantee: | Gleice Kelli Ribeiro da Silva Cardoso |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/05957-8 - Epilepsies and neuropsyquiatric comorbidities: characterization of the effects of the treatment with cannabidiol and HUF-101 in in vivo and in vitro experimental models |
| Grantee: | Norberto Garcia Cairasco |
| Support Opportunities: | Regular Research Grants |