| Full text | |
| Author(s): Show less - |
Gorjao, R.
;
Hirabara, S. M.
;
Masi, L. N.
;
Serdan, T. D. A.
;
Gritte, R. B.
;
Hatanaka, E.
;
Souza-Siqueira, T.
;
Pithon-Curi, A. C.
;
de Lima, T. M.
;
Pithon-Curi, T. C.
;
Marchini, J. F. M.
;
Machado, M. C. C.
;
Souza, H. P.
;
Curi, R.
Total Authors: 14
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 55, n. 1, p. 11-pg., 2022-01-01. |
| Abstract | |
Diabetes is associated with a worse prognosis and a high risk of morbidity and mortality in COVID-19 patients. We aimed to evaluate the main factors involved in the poor prognosis in diabetic patients. A total of 984 patients diagnosed with COVID-19 admitted to the hospital were included in this study. Patients were first divided into type-2 diabetic (DM + ) and non-diabetic (DM-) groups. The participants were analyzed based on the National Early Warning Score (NEWS) and on the Quick-Sequential Organ Failure Assessment (qSOFA) to find the best prognostic risk score for our study. The DM + and DM- groups were divided into non-severe and severe groups. Comparative and correlative analyses were used to identify the physiological parameters that could be employed for creating a potential risk indicator for DM + COVID-19 patients. We found a poorer prognosis for the DM + COVID-19 patients with a higher ICU admission rate, mechanical ventilation rate, vasopressor use, dialysis, and longer treatment times compared with the DM- group. DM + COVID-19 patients had increased plasma glucose, lactate, age, urea, NEWS, and D-dimer levels, herein referred to as the GLAUND set, and worse prognosis and outcomes when compared with infected DM- patients. The NEWS score was a better indicator for assessing COVID-19 severity in diabetic patients than the q-SOFA score. In conclusion, diabetic COVID-19 patients should be assessed with the NEWS score and GLAUND set for determining their prognosis COVID-19 prognosis. (AU) | |
| FAPESP's process: | 18/09868-7 - Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise |
| Grantee: | Rui Curi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/04738-8 - Patients with Severe Acute Respiratory Syndrome due to COVID-19 in an emergency department |
| Grantee: | Heraldo Possolo de Souza |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/08624-0 - Post-COVID Sydrom: immunological sequelae after COVID-19 infection |
| Grantee: | Marcel Cerqueira Cesar Machado |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/25892-8 - Reversal of spontaneous Type 2 Diabetes by bone marrow transplant |
| Grantee: | Laureane Nunes Masi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/07283-1 - Effects of leptin on lymphocyte differentiation and metabolism |
| Grantee: | Renata Gorjao |
| Support Opportunities: | Regular Research Grants |