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Greener Synthesis of Pyrroloquinazoline Derivatives: Recent Advances

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Author(s):
Moreira, Natalia M. ; dos Santos, Jhonathan R. N. ; Correa, Arlene G.
Total Authors: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. N/A, p. 30-pg., 2022-06-13.
Abstract

Quinazoline derivatives draw attention from a synthetic and medicinal chemistry point of view, given the wide range of biological activities already described. This class of fused N-heterocyclic compounds has also shown its importance and potential pharmacological application. This Review covers the contributions reported in the last ten years for the synthesis of pyrroloquinazoline derivatives, focusing on greener protocols to obtain these adducts, such as multicomponent reactions, photocatalysis, microwaves, electrosynthesis among others. (AU)

FAPESP's process: 17/19940-4 - Synthesis and evaluation of antiparasitic activity of quinazolines employing multicomponent reactions and C-H functionalization
Grantee:Natália Menezes Moreira Borges
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 20/10349-4 - Synthesis of fused N-heterocycles employing C-H functionalization reactions and evaluation of antiparasitary activity
Grantee:Natália Menezes Moreira Borges
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support Opportunities: Research Grants - Research Centers in Engineering Program