Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats

Author(s)

Galan, B. S. M. ; Serdan, T. D. A. ; Rodrigues, L. E. ; Manoel, R. ; Gorjao, R. ; Masi, L. N. ; Pithon-Curi, T. C. ; Curi, R. ; Hirabara, S. M.

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 55, n. 1, p. 14-pg., 2022-01-01.

Abstract

There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats. (AU)

• FAPESP's process: 18/09868-7 - Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise
• Grantee: Rui Curi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/06641-1 - Evaluation of molecular markers involved with leukocyte function and activation in Goto-Kakizaki rats by flow cytometry.
• Grantee: Bryan Steve Martinez Galan
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 20/06642-8 - Analysis of mRNA expression of inflammatory markers in skeletal muscle, white adipose tissue, macrophages and lymphocytes from Goto-Kakizaki rats.
• Grantee: Richelieau Manoel
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 19/25892-8 - Reversal of spontaneous Type 2 Diabetes by bone marrow transplant
• Grantee: Laureane Nunes Masi
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/07283-1 - Effects of leptin on lymphocyte differentiation and metabolism
• Grantee: Renata Gorjao
• Support Opportunities: Regular Research Grants