Advanced search
Start date

Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Full text
Rogerio, Carolina B. ; Abrantes, Daniele Carvalho ; de Oliveira, Jhones L. ; de Araujo, Daniele Ribeiro ; da Costa, Tais Germano ; de Lima, Renata ; Fraceto, Leonardo Fernandes
Total Authors: 7
Document type: Journal article
Source: ACS APPLIED BIO MATERIALS; v. 5, n. 3, p. 11-pg., 2022-03-21.

The most important arboviruses are those that cause dengue, yellow fever, chikungunya, and Zika, for which the main vector is the Aedes aegypti mosquito. The use of repellents is an important way to combat mosquito-borne pathogens. In this work, a safe method of protection employing a repellent was developed based on a slow release system composed of zein nanoparticles containing the active agents icaridin and geraniol incorporated in a cellulose gel matrix. Analyses were performed to characterize the nanoparticles and the gel formulation. The nanoparticles containing the repellents presented a hydrodynamic diameter of 229 +/- 9 nm, polydispersity index of 0.38 +/- 0.10, and zeta potential of +29.4 +/- 0.8 mV. The efficiencies of encapsulation in the zein nanoparticles exceeded 85% for icaridin and 98% for geraniol. Rheological characterization of the gels containing nanoparticles and repellents showed that the viscoelastic characteristic of hydroxypropylmethylcellulose gel was preserved. Release tests demonstrated that the use of nanoparticles in combination with the gel matrix led to improved performance of the formulations. Atomic force microscopy analyses enabled visualization of the gel network containing the nanoparticles. Cytotoxicity assays using 3T3 and HaCaT cell cultures showed low toxicity profiles for the active agents and the nanoparticles. The results demonstrated the potential of these repellent systems to provide prolonged protection while decreasing toxicity. (AU)

FAPESP's process: 20/05415-8 - Development of larvicide from lignin nanoparticles containing natural assets to combat the spread of arboviruses
Grantee:Carolina Barbara Rogerio
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/02404-5 - Hydrogels containing the geraniol and icaridine repellents encapsulated in zein nanoparticles as an alternative to combat arboviruses
Grantee:Carolina Barbara Rogerio
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/21142-1 - Encapsulation of Bacillus thuringiensis (Bacillales: Bacillaceae) in polymeric microparticles and association with nanoencapsulated chemical agent: evaluation of biological activity and mechanisms of action
Grantee:Jhones Luiz de Oliveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral