Hydrogels containing the geraniol and icaridine repellents encapsulated in zein nanoparticles as an alternative to combat arboviruses

• Grant number: 18/02404-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): June 01, 2018
• Effective date (End): December 31, 2019
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Leonardo Fernandes Fraceto
• Grantee: Carolina Barbara Rogerio
• Host Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil

Abstract

Changes in the environment, such as population growth, the process of globalization and climate change are some of the contributions to the emergence of epidemics. The main arboviruses that affect the country are Dengue, Yellow Fever, Chikungunya and Zika, which have the mosquito Aedes aegypti as the main vector. Such diseases present several symptoms such as fever, headache, rash, malaise, edema and joint pain. The use of repellents, have been one of the methods used to protect against the mosquito. Being that these products act by forming a layer on the skin with repulsive odor to the insect. However, some commonly used repellents have been shown to be toxic, especially for pregnant women and newborns. It should be noted that these groups are classified as at risk for vaccination (in the case of yellow fever), which increases the risks and the possibility of infection. In this context, the present project aims to develop a repellent based on slow release systems, from zein nanoparticles containing the active Icaridin and Geraniol incorporated into a cellulose gel matrix. These systems would allow a reduction of the amount of active, reduction of the toxicity besides the fact that the use of mixture of assets could allow the reduction of processes of resistance by the insects. In addition, stability and release assays of the hydrogel actives to be formulated will be performed. Thus, the present proposal emerged from the motivation to develop long-lasting repellents that can protect the population and also ensure health and well-being, especially to pregnant women and newborns due to the search for systems that have low toxicity and high efficacy. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ABRANTES, DANIELE CARVALHO; ROGERIO, CAROLINA BARBARA; DE OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; DE ARAUJO, DANIELE RIBEIRO; PAMPANA, LAURINDO CESAR; DUARTE, MARCELO JOSE; VALADARES, GEORGIO FREESZ; FRACETO, LEONARDO FERNANDES. Development of a Mosquito Repellent Formulation Based on Nanostructured Lipid Carriers. FRONTIERS IN PHARMACOLOGY, v. 12, OCT 11 2021. (18/02404-5, 17/24402-1, 18/14734-0, 20/12779-6)

CAMPOS, ESTEFANIA VANGELIE RAMOS; DE OLIVEIRA, JHONES LUIZ; ABRANTES, DANIELE CARVALHO; ROGERIO, CAROLINA BARBARA; BUENO, CAROLINA; MIRANDA, VANESSA REGINA; MONTEIRO, RENATA APARECIDA; FRACETO, LEONARDO FERNANDES. Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 8, FEB 20 2020. (17/24402-1, 18/02404-5)

ROGERIO, CAROLINA B.; ABRANTES, DANIELE CARVALHO; DE OLIVEIRA, JHONES L.; DE ARAUJO, DANIELE RIBEIRO; DA COSTA, TAIS GERMANO; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control. ACS APPLIED BIO MATERIALS, v. 5, n. 3, p. 11-pg., 2022-03-21. (20/05415-8, 18/02404-5, 18/21142-1)

ABRANTES, DANIELE CARVALHO; ROGERIO, CAROLINA BARBARA; CAMPOS, ESTEFANIA VANGELIE RAMOS; GERMANO-COSTA, TAIS; VIGATO, ARYANE ALVES; MACHADO, IAN POMPERMEYER; SEPULVEDA, ANDERSON FERREIRA; LIMA, RENATA; DE ARAUJO, DANIELE RIBEIRO; FRACETO, LEONARDO FERNANDES. Repellent active ingredients encapsulated in polymeric nanoparticles: potential alternative formulations to control arboviruses. JOURNAL OF NANOBIOTECHNOLOGY, v. 20, n. 1, p. 16-pg., 2022-12-10. (17/24402-1, 19/14773-8, 18/02404-5, 18/14734-0)

GERMANO-COSTA, T.; BILESKY-JOSE, N.; GUILGER-CASAGRANDE, M.; PASQUOTO-STIGLIANI, T.; ROGERIO, CB.; ABRANTES, DC.; MARUYAMA, CR.; OLIVEIRA, JL.; FRACETO, LF.; LIMA, R.. Use of 2D and co-culture cell models to assess the toxicity of zein nanoparticles loading insect repellents icaridin and geraniol. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 216, p. 12-pg., 2022-08-01. (20/05816-2, 17/20932-6, 18/14734-0, 15/18231-4, 17/25702-9, 18/02404-5)