Unequal burden of Zika-associated microcephaly among populations with public and private healthcare in Salvador, Brazil

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Aromolaran, Adeolu ; Araujo, Katiaci ; Ladines-Lim, Joseph B. ; Nery Jr, Nivison ; Rosario, Mateus S. do ; Rastely Jr, Valmir N. ; Archanjo, Gracinda ; Daltro, Dina ; Carvalho, Gustavo Baltazar da Silveira ; Pimentel, Kleber ; Almeida, Joao Ricardo Maltez de ; Siqueira, Isadora Cristina de ; Ribeiro, Hugo C. ; Oliveira-Filho, Jamary ; de Oliveira, Daiana ; Henriques, Daniele F. ; Rodrigues, Sueli G. ; Vasconcelos, Pedro F. da Costa ; de Almeida, Antonio R. P. ; Sacramento, Gielson A. ; Cruz, Jaqueline S. ; Sarno, Manoel ; Freitas, Bruno de Paula ; Mattos, Adriana ; Khouri, Ricardo ; Reis, Mitermayer G. ; Ko, Albert I. ; Costa, Federico

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES; v. 120, p. 4-pg., 2022-07-01.

Abstract

Objectives: To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals in Salvador, Brazil that serve patients of different socioeconomic status (SES). Methods: Clinical and serologic data were collected prospectively from pregnant women and their infants, who delivered at 2 study centers during the 2015-2016 Zika virus (ZIKV) epidemic in Salvador, Brazil. Results: Pregnant women from Salvador, Brazil delivering in a low SES hospital had 3 times higher ZIKV exposure rate than women at a high SES hospital. However, different SES hospitals had similar prevalence of infants with CZS-associated microcephaly (10% vs 6%, p = 0.16) after controlling for ZIKV exposure in their mothers. Conclusions: Our study supports the positive association between low SES, high maternal ZIKV exposure, and high rates of CZS-associated microcephaly. (c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) (AU)

• FAPESP's process: 16/08727-5 - Development of serological assay for Zika virus IgG and IgM based on low coast ELISA
• Grantee: Danielle Bruna Leal de Oliveira
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE