Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications

Author(s)

Barbosa, Karla A. ; Rodrigues, Isabella C. P. ; Tamborlin, Leticia ; Luchessi, Augusto D. ; Lopes, Eder S. N. ; Gabriel, Lais P.

• Document type: Journal article
• Source: JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T; v. 18, p. 10-pg., 2022-05-01.

Abstract

Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 mm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). (AU)

• FAPESP's process: 20/07923-0 - Development of bioactive bioinks and production of bioabsorbable custom scaffolds by additive manufacturing and rotary jet spinning to bone tissue repair
• Grantee: Laís Pellizzer Gabriel
• Support Opportunities: Regular Research Grants