| Full text | |
| Author(s): |
Gomes, Fernando Ribeiro
;
Madelaire, Carla Bonetti
;
Moretti, Eduardo Hermogenes
;
Monteiro Titon, Stefanny Christie
;
Assis, Vania Regina
Total Authors: 5
|
| Document type: | Journal article |
| Source: | INTEGRATIVE AND COMPARATIVE BIOLOGY; v. N/A, p. 17-pg., 2022-04-12. |
| Abstract | |
This paper reviews several aspects of immunoendocrinology and ecoimmunology in Brazilian species of anurans under investigation for more than a decade, including (1) patterns of annual covariation of circulating steroids, calling behavior and innate immunity, (2) endocrine and immune correlates of calling performance, (3) behavioral and physiological correlates of parasite load, (4) thermal sensitivity of immune function, and (5) endocrine and immunomodulation by experimental exposure to acute and chronic stressors, as well as to endocrine manipulations and simulated infections. Integrated results have shown an immunoprotective role of increased steroid plasma levels during reproductive activity in calling males. Moreover, a higher helminth parasite load is associated with changes in several behavioral and physiological traits under field conditions. We also found anuran innate immunity is generally characterized by eurythermy, with maximal performance observed in temperatures close to normal and fever thermal preferendum. Moreover, the aerobic scope of innate immune response is decreased at fever thermal preferendum. Experimental exposure to stressors results in increased corticosterone plasma levels and immune redistribution, with an impact on immune function depending on the duration of the stress exposure. Interestingly, the fate of immunomodulation by chronic stressors also depends in part on individual body condition. Acute treatment with corticosterone generally enhances immune function, while prolonged exposure results in immunosuppression. Still, the results of hormonal treatment are complex and depend on the dose, duration of treatment, and the immune variable considered. Finally, simulated infection results in complex modulation of the expression of cytokines, increased immune function, activation of the Hypothalamus-Pituitary-Interrenal axis, and decreased activity of the Hypothalamus-Pituitary-Gonadal axis, as well as reduced melatonin plasma levels, suggesting that anurans have a functional Immune-Pineal axis, homologous to that previously described for mammals. These integrated and complementary approaches have contributed to a better understanding of physiological mechanisms and processes, as well as ecological and evolutionary implications of anuran immunoendocrinology. (AU) | |
| FAPESP's process: | 15/23801-4 - Immunomodulatory effects of acute stress in toads from Genus Rhinella |
| Grantee: | Vania Regina de Assis |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/09399-7 - Development of hypothermia in systemic inflammation: the brain hypoxia hypothesis |
| Grantee: | Eduardo Hermogenes Moretti |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 11/03030-2 - Sazonal relationship between testosterone, reprodution, immunocompetence and endoparasites in anuran amphibians of caatinga |
| Grantee: | Carla Bonetti Madelaire |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 14/16320-7 - Impacts of climate/environmental change on the fauna: an integrative approach |
| Grantee: | Carlos Arturo Navas Iannini |
| Support Opportunities: | Research Program on Global Climate Change - Thematic Grants |
| FAPESP's process: | 19/24950-4 - Temporal dynamics of the inflammatory response in amphibians |
| Grantee: | Fernando Ribeiro Gomes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/00406-0 - SEASONAL RELATIONSHIP BETWEEN IMMUNOCOMPETENCE, STERIODS AND STRESS RESPONSE IN ECTOTERMS |
| Grantee: | Carla Bonetti Madelaire |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |