Functionalized lipid-based drug delivery nanosystems for the treatment of human infectious diseases

Author(s)

Almeida Furquim de Camargo, Bruna ; Fonseca-Santos, Bruno ; Goncalves Carvalho, Suzana ; Correa Carvalho, Gabriela ; Delello Di Filippo, Leonardo ; Sousa Araujo, Victor Hugo ; Lobato Duarte, Jonatas ; Polli Silvestre, Amanda Leticia ; Bauab, Tais Maria ; Chorilli, Marlus

• Document type: Journal article
• Source: CRITICAL REVIEWS IN MICROBIOLOGY; v. N/A, p. 17-pg., 2022-05-28.

Abstract

Infectious diseases are still public health problems. Microorganisms such as fungi, bacteria, viruses, and parasites are the main causing agents related to these diseases. In this context, the search for new effective strategies in prevention and/or treatment is considered essential, since current drugs often have side effects or end up, causing microbial resistance, making it a serious health problem. As an alternative to these limitations, nanotechnology has been widely used. The use of lipid-based drug delivery nanosystems (DDNs) has some advantages, such as biocompatibility, low toxicity, controlled release, the ability to carry both hydrophilic and lipophilic drugs, in addition to be easel scalable. Besides, as an improvement, studies involving the conjugation of signalling molecules on the surfaces of these nanocarriers can allow the target of certain tissues or cells. Thus, this review summarizes the performance of functionalized lipid-based DDNs for the treatment of infectious diseases caused by viruses, including SARS-CoV-2, bacteria, fungi, and parasites. (AU)

• FAPESP's process: 19/26821-7 - Nano-in-nano containing curcumin and benzydamine hydrochloride for the treatment of Vulvovaginal Candidiasis: from development to biological application in vitro and in vivo
• Grantee: Gabriela Corrêa Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/10261-2 - Evaluation of the potential of nanostructured lipid carriers for co-encapsulation of curcumin and fluconazole dispersed in thermally-responsive hydrogels in the treatment of vulvovaginal candidiasis
• Grantee: Victor Hugo Sousa Araujo
• Support Opportunities: Scholarships in Brazil - Doctorate