| Full text | |
| Author(s): |
Bertuzzi, Diego L.
;
Braga, Carolyne B.
;
Perli, Gabriel
;
Ornelas, Catia
Total Authors: 4
|
| Document type: | Journal article |
| Source: | European Journal of Inorganic Chemistry; v. 2022, n. 9, p. 6-pg., 2022-02-01. |
| Abstract | |
Combination of advantages of ferrocenyl compounds and multifunctional dendrimer scaffold afforded a water-soluble well-defined bifunctional dendrimer with polyamide backbone and thirty two termini: eighteen carboxylic acid groups and eighteen triazolylferrocenyl moieties. The structure of the new dendrimer was thoroughly characterized by nuclear magnetic resonance (NMR) spectroscopy, absorbance spectroscopy in the UV-vis, and MALDI-TOF mass spectrometry. The MALDI-TOF spectrum of the final dendrimer showed the [M](2+) ion peak at 4820.1 m/z unambiguously confirming the successful synthesis of the water-soluble well-defined bifunctional dendrimer. The cytotoxicity of the well-defined bifunctional triazolylferrocenyl dendrimer 4 was evaluated against MCF-7 (breast adenocarcinoma), HeLa (cervical cancer), PC3 (prostate adenocarcinoma), Caco-2 (colorectal cancer), and PNT2 (normal prostate cells) cell lines. The cytotoxicity assays showed that the dendrimer exhibits moderate anticancer activity and targets cancer cells selectively over normal cells. (AU) | |
| FAPESP's process: | 17/06146-8 - Development of nanocarriers based on dendrimers and polymer nanoparticles for selective delivery of goniothalamin, piplartine and Monastrol |
| Grantee: | Carolyne Brustolin Braga |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/04929-0 - Development of biosensors for instantaneous detection of proteins and cancer cells, for application on on-site biopsy |
| Grantee: | Diego Luan Bertuzzi |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 21/00555-9 - Development of polymeric nanoparticles and multifunctional dendrimers for drug delivery |
| Grantee: | Igor Dias Jurberg |
| Support Opportunities: | Regular Research Grants |