| Full text | |
| Author(s): Show less - |
Carla Evelyn Coimbra Nunez
[1]
;
Joaquim Barreto Oliveira
[2]
;
Silvia de Barros-Mazon
[3]
;
Vanessa H. S. Zago
[4]
;
Denise Beheregaray Kaplan
[5]
;
Ruy T. Nakamura
[6]
;
Magnus Ake Gidlund
[7]
;
Erica I. L. Gomes
[8]
;
Patricia Miralda Cazita
[9]
;
Edna Nakandakare
[10]
;
Helison R. Carmo
[11]
;
Andrei C. Sposito
[12]
;
Eliana Cotta de Faria
[13]
Total Authors: 13
|
| Affiliation: Show less - | [1] Universidade Estadual de Campinas. Departamento de Patologia - Brasil
[2] Universidade Estadual de Campinas. Laboratório de Aterosclerose e Biologia Vascular - Brasil
[3] Universidade Estadual de Campinas. Departamento de Patologia - Brasil
[4] Pontifícia Universidade Católica - Brasil
[5] Universidade Estadual de Campinas. Departamento de Patologia - Brasil
[6] Diagnostic Image Laboratory - Brasil
[7] Universidade de São Paulo - Brasil
[8] Universidade Estadual de Campinas - Brasil
[9] Universidade de São Paulo - Brasil
[10] Universidade de São Paulo - Brasil
[11] Universidade Estadual de Campinas - Brasil
[12] Universidade Estadual de Campinas. Laboratório de Aterosclerose e Biologia Vascular - Brasil
[13] Universidade Estadual de Campinas. Departamento de Patologia - Brasil
Total Affiliations: 13
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Cardiologia; 2022-09-02. |
| Abstract | |
Abstract Background In the atherosclerotic plaque microenvironment, oxidized phospholipids expressed in the oxidized low-density lipoprotein (oxLDL) surface bind to scavenger receptors of macrophages eliciting foam cell formation and plaque progression. Auto-antibodies against oxLDL (oxLDL-Ab) interact with oxidative epitopes leading to the formation of immune complexes that are unable to interact with macrophage receptors, thus abrogating atherogenesis. Release of oxLDL-Ab by B cells involves interleukin 5 and Th2 response, which in turn are potentiated by HDL. Thereby, we hypothesized that individuals with higher levels of HDL-C may plausibly display elevated titers of oxLDL-Ab. Objective To evaluate the relationship between HDL-C and oxLDL-Ab levels. Methods Asymptomatic individuals (n = 193) were grouped according to their HDL-C concentration to one of three categories: low (< 68 mg/dL), intermediate (68 to 80 mg/dL) or high (> 80 mg/dL). P values < 0.05 were considered statistically significant. Results Our analysis included 193 individuals (mean age: 47 years; male: 26.3%). Compared to individuals in the lowest HDL-C tertile, those in the highest tertile were older (36 versus 53 years; p = 0.001) and less frequently male (42.6% versus 20.9%; p = 0.001). Mean values of oxLDL-Ab increased as the HDL-C group escalated (0.31, 0.33 and 0.43 units, respectively; p = 0.001 for trend). Simple linear regression found a significant, positive relationship between the independent variable, HDL-C, and the dependent variable, oxLDL-Ab (R = 0.293; p = 0.009). This relation remained significant (R = 0.30; p = 0.044), after adjustment by covariates. Apolipoprotein AI levels were also related to oxLDL-Ab in both simple and adjusted linear regression models. Conclusion HDL-C and oxLDL-Ab are independently related. (AU) | |
| FAPESP's process: | 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters |
| Grantee: | Eder Carlos Rocha Quintão |
| Support Opportunities: | Research Projects - Thematic Grants |