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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between ACE and ACTN3 genetic polymorphisms and the effects of different physical training models on physically active women aged 50 to 75

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Author(s):
KARINE P. RODRIGUES [1] ; LAIS S. PRADO [2] ; MARIANA LUCIANO DE ALMEIDA [3] ; ATILA ALEXANDRE TRAPE [4] ; CARLOS ROBERTO BUENO JUNIOR
Total Authors: 5
Affiliation:
[1] University of São Paulo. School of Physical Education and Sport of Ribeirão Preto - Brasil
[2] University of Franca. Health Promotion Program - Brasil
[3] University of São Paulo. School of Nursing of Ribeirao Preto - Brasil
[4] University of São Paulo. School of Physical Education and Sport of Ribeirão Preto - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Anais da Academia Brasileira de Ciências; v. 94, 2022-10-03.
Abstract

Abstract The aim of this study was to analyze the association between ACE (DD + ID versus II) and ACTN3 (TT + TC versus CC) polymorphisms in the response of multicomponent physical training programs and combined in the health parameters of physically active women aged 50 to 75 years. Participants were randomly divided into two groups: multi-component training and combined training. Intervention lasted 14 weeks, 180 minutes a week. Genomic DNA was extracted from blood samples and genotyping analyzes were performed by conventional and real-time PCR. Associations were observed between polymorphisms in anthropometric measurements, blood pressure, physical capacity and quality of life in both models physical training, with improvement in group II - (ACE- multicomponent training in terms of abdominal circumference and sit-to - Combined training in terms of waist circumference) and TT + TC group (ACTN3 - multicomponent training in tests of muscle strength and mental quality of life domain, and combined training in body mass index, waist circumference, diastolic blood pressure, upper limb strength and cardiorespiratory capacity). Fourteen weeks of multicomponent and combined physical training in physically active women aged 50 to 75 years resulted in greater health benefits for genotypes II (ACE) and TT + TC (ACTN3). (AU)

FAPESP's process: 13/21159-8 - Influence of genetics polymorphisms in effects of two types of high intensity aerobic interval training in patients with metabolic syndrome
Grantee:Carlos Roberto Bueno Júnior
Support Opportunities: Regular Research Grants
FAPESP's process: 17/21361-2 - Global screening of genetic and epigenetic factors associated with magnitude of response to different physical training protocols in women 50-70 years
Grantee:Carlos Roberto Bueno Júnior
Support Opportunities: Regular Research Grants