Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?

Author(s)

de Lima, Gabriela Trzewikoswki ; De Gaspari, Elizabeth

• Document type: Journal article
• Source: JOURNAL OF AGING RESEARCH; v. 2019, p. 8-pg., 2019-01-01.

Abstract

Literature reports the association between aging and decline in the immune system function. The elderly have a higher risk of developing infectious diseases and are often less responsive to vaccines that are effective in the young. The case fatality rate of invasive meningococcal disease is higher in the elderly; therefore, vaccination for this population should be evaluated. Although new vaccines have been developed against Neisseria meningitidis, there is still a need to evaluate a vaccine for those older than 60 years, as the currently licensed vaccines are not indicated for this population. (AU)

• FAPESP's process: 13/11147-2 - Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of different immunization schedules in different strains of mice
• Grantee: Luciana Tendolini Brito
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/17945-1 - Comparative study of ELISA and ELISPOT techniques in the detection of antibodies IgG, IgM in isogenic strains of elderly mice
• Grantee: Thais Sousa Rodrigues
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/04202-0 - Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of new adjuvant for Neisseria meningitidis in different strains of elderly mice
• Grantee: Elizabeth Natal de Gaspari
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/15568-0 - Study of the immunogenicity of outer membrane antigens of Neisseria meningitidis and interaction with cationic lipids: evaluation of different immunization schedules in different strains of mice
• Grantee: Elizabeth Natal de Gaspari
• Support Opportunities: Regular Research Grants