| Full text | |
| Author(s): |
de Oliveira, Matheus F.
;
da Silva, Laura C. E.
;
Catori, Daniele M.
;
Lorevice, Marcos, V
;
Galvao, Karen E. A.
;
Millas, Ana L. G.
;
de Oliveira, Marcelo G.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Macromolecular Bioscience; v. N/A, p. 14-pg., 2022-12-25. |
| Abstract | |
The design of bioresorbable vascular stents (BVS) capable of releasing nitric oxide (NO) at the implant site may enable BVS to mimic the antiplatelet, antiproliferative, and pro-endothelial actions of NO, overcoming complications of BVS such as late thrombosis and restenosis. In this study, the fabrication of BVS composed of methacrylated poly(dodecanediol citrate-co-dodecanediol S-nitroso-mercaptosuccinate) (mP(DC-co-DMSNO)), a novel elastomeric, bioabsorbable, and photocurable copolyester, containing covalently bound S-nitrosothiol groups in the carbon backbone of the polymer, is reported. The mP(DC-co-DMSNO) stents are manufactured via photoinduced 3D printing and allow deployment via a self-expansion process from a balloon catheter. After deployment, hydration of the stents triggers the release of NO, which is maintained during the slow hydrolysis of the polymer. Real-time NO release measurements show that by varying the copolyester composition and the strut geometry of the mP(DC-co-DMSNO) stents, it is possible to modulate their NO release rate in the range of 30-52 pmol min(-1) cm(-2). Preliminary biological assays in cell culture show that endothelial cells adhere to the surface of the stents and that NO release favors their endothelization. Thus, mP(DC-co-DMSNO) may emerge as a new platform for the fabrication of advanced BVS. (AU) | |
| FAPESP's process: | 18/02520-5 - Nitric oxide-releasing stents comprised of bioabsorbable polinitrosated polyesters |
| Grantee: | Matheus Fernandes de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release |
| Grantee: | Marcelo Ganzarolli de Oliveira |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/14142-5 - Hybrid hydrogels for local and prolonged nitric oxide release |
| Grantee: | Laura Caetano Escobar da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 21/00491-0 - Thermo-sensitive Pluronic F127 hydrogels with functionalized nitric oxide-releasing end groups |
| Grantee: | Marcos Vinicius Lorevice |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |