| Full text | |
| Author(s): Show less - |
Sato, Joao Ricardo
;
Biazoli, Claudinei Eduardo
;
Bueno, Ana Paula Arantes
;
Caye, Arthur
;
Pan, Pedro Mario
;
Santoro, Marcos
;
Honorato-Mauer, Jessica
;
Salum, Giovanni Abrahao
;
Hoexter, Marcelo Queiroz
;
Bressan, Rodrigo Affonseca
;
Jackowski, Andrea Parolin
;
Miguel, Euripedes Constantino
;
Belangero, Sintia
;
Rohde, Luis Augusto
Total Authors: 14
|
| Document type: | Journal article |
| Source: | GENES BRAIN AND BEHAVIOR; v. N/A, p. 9-pg., 2023-02-21. |
| Abstract | |
Neuroimaging studies suggest that brain development mechanisms might explain at least some behavioural and cognitive attention-deficit/hyperactivity disorder (ADHD) symptoms. However, the putative mechanisms by which genetic susceptibility factors influence clinical features via alterations of brain development remain largely unknown. Here, we set out to integrate genomics and connectomics tools by investigating the associations between an ADHD polygenic risk score (ADHD-PRS) and functional segregation of large-scale brain networks. With this aim, ADHD symptoms score, genetic and rs-fMRI (resting-state functional magnetic resonance image) data obtained in a longitudinal community-based cohort of 227 children and adolescents were analysed. A follow-up was conducted approximately 3 years after the baseline, with rs-fMRI scanning and ADHD likelihood assessment in both stages. We hypothesised a negative correlation between probable ADHD and the segregation of networks involved in executive functions, and a positive correlation with the default-mode network (DMN). Our findings suggest that ADHD-PRS is correlated with ADHD at baseline, but not at follow-up. Despite not surviving for multiple comparison correction, we found significant correlations between ADHD-PRS and segregation of cingulo-opercular networks and DMN at baseline. ADHD-PRS was negatively correlated with the segregation level of cingulo-opercular networks but positively correlated with the DMN segregation. These directions of associations corroborate the proposed counter-balanced role of attentional networks and DMN in attentional processes. However, the association between ADHD-PRS and brain networks functional segregation was not found at follow-up. Our results provide evidence for specific influences of genetic factors on development of attentional networks and DMN. We found significant correlations between polygenic risk score for ADHD (ADHD-PRS) and segregation of cingulo-opercular networks and default-mode network (DMN) at baseline. ADHD-PRS was negatively correlated with the segregation level of cingulo-opercular networks but positively correlated with the DMN segregation. (AU) | |
| FAPESP's process: | 18/04654-9 - Time series, wavelets and high dimensional data |
| Grantee: | Pedro Alberto Morettin |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/13737-0 - Polygenic score and transcriptomic analysis in children and teenagers at risk to psychiatric disorders |
| Grantee: | Marcos Leite Santoro |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study |
| Grantee: | Andrea Parolin Jackowski |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/05332-8 - Brazilian high-risk cohort for psychiatric disorders: 10 years follow-up |
| Grantee: | Rodrigo Affonseca Bressan |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/04983-7 - Neuroimaging, genomics, transcriptomics and epigenomics: dealing with big data toward an integrative model of mental disorders |
| Grantee: | Jair de Jesus Mari |
| Support Opportunities: | Research Grants - eScience and Data Science Program - Regular Program Grants |
| FAPESP's process: | 18/21934-5 - Network statistics: theory, methods, and applications |
| Grantee: | André Fujita |
| Support Opportunities: | Research Projects - Thematic Grants |